Cancer cell-cell interaction: Notch-1 signaling pathway and its regulation mechanisms
10.3871/j.1004-7220.2016.03.284
- VernacularTitle:肿瘤细胞间相互作用：Notch-1信号转导与调控机制
- Author:
Li LI
1
;
Ni-ya XIONG
1
;
Jing ZHANG
1
;
Hong YANG
1
;
Chun-hui WU
1
;
Yi-yao LIU
1
Author Information
1. Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China
- Publication Type:Journal Article
- Keywords:
Notch-1 signaling;
Cell-cell interaction;
Tumor cells;
Cell adhesion;
Cancer metastasis
- From:
Journal of Medical Biomechanics
2016;31(3):E284-E290
- CountryChina
- Language:Chinese
-
Abstract:
Notch-1 signaling pathway is responsible for cell differentiation, development, proliferation and apoptosis. Recent studies show that Notch-1 signaling pathway is also involved in cancer progression, including cell invasion, motility and cancer metastasis. Activation of Notch-1 signaling pathway can directly or indirectly induce cell proliferation and migration. In tumor cells, activation of Notch-1 facilitates epithelial-mesenchymal transition (EMT), keeps its mesenchyme characteristics and induces cell adhesion. Notch-1 signaling pathway also cross-talks with other pathways to regulate cell fate, such as PI3K/Akt, NF-κB pathways. The evidence shows that aberrant Notch-1 activation has been found in different solid tumors, which participates in regulating tumor metastasis. In this review, the Notch structure and function, Notch-1 signal and tumorigenesis, tumor metastasis via Notch-1 signaling, and Notch-1 signaling targeted-therapy were comprehensively summarized. To clarify the roles of Notch-1 signal pathway in tumor metastasis and its regulatory mechanisms as well as the current treatment strategies for Notch-1 signal pathway will provide references for studies on pathomechanism and clinical treatment of cancers.
