Influence of Microscale Attractive Interaction on Elastic Property of DNA Biofilm
10.16156/j.1004-7220.2018.04.10
- VernacularTitle:微观吸引作用对DNA膜弹性性质的影响
- Author:
Xiaobin LI
1
;
Yimin YE
1
;
Wei LU
1
;
Meihong ZHOU
1
;
Nenghui ZHANG
2
Author Information
1. Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanic
2. Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanic;Department of Mechanics, College of Sciences, Shanghai University
- Publication Type:Journal Article
- Keywords:
DNA film;
micro-scale attractive interaction;
electrostatic zipper model;
tensile prestress;
negative elastic modulus
- From:
Journal of Medical Biomechanics
2018;33(4):E348-E353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of the microscale attractive interaction on the elastic properties of DNA film in multivalent ion solutions. Methods Kornyshev's electrostatic zipper model was employed to describe the interaction energy between the DNA strands. The thought experiment method and macroscopic continuum bar model were combined to predict the stress-strain relationship, prestress, and elastic modulus of the DNA biofilm.Results Given the packing conditions, the DNA film exhibited a tensile prestress and negative elastic modulus. The prestress of the DNA biofilm ranged from -1.52 MPa to 1.17 MPa, and its elastic modulus ranged from -4.2 MPa to 64 MPa. Conclusions In contrast with monovalent solutions, the microscopic attractive interactions in multivalent solutions caused the elastic properties of the DNA film to exhibit a non-monotonous relationship with the variation in the packing density and salt concentration. The tensile elastic properties were significantly different from the compressive ones, and the tensile/compressive prestress as well as the positive/negative elastic modulus transformed each other. These results can contribute to understanding the mechanism of viral replication and provide references for gene detection and gene therapy.
