Clinical characteristics of rare Streptococcal pneumonia disease in children
10.3760/cma.j.issn.2095-428X.2019.22.002
- VernacularTitle: 儿童少见肺炎链球菌病的临床特征
- Author:
Kai ZHOU
1
;
Qing HAN
2
Author Information
1. Department of Infectious Disease, Children′s Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China
2. Department of Respiratory, Children′s Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China
- Publication Type:Journal Article
- Keywords:
Streptococcus pneumoniae disease;
Overwhelming post-splenectomy infection;
Purpura fulminans;
Austrian′s syndrome
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(22):1685-1689
- CountryChina
- Language:Chinese
-
Abstract:
The clinical manifestations of Streptococcus pneumoniae disease(SPD) are various, and some patients with rare SPD types have a worse prognosis.Among them, the mortality is up to 70% after 48-72 hours of the onset of Streptococcus pneumoniae (SP)-related overwhelming post-splenectomy infection(OPSI). Purpura fulminans of SP(SP-PF) is often characterized by extensive purpura, fever, hypotension and disseminated intravascular coagulation, and prognosis of the patients without prodromal symptoms is poor.Infectious endocarditis has a mortality rate of 20.7% in SP-related cardiovascular diseases, and Austrian syndrome has a fatality rate of 43.5%.The mortality rate of bacterial pericarditis was 13.56%.At present, SP vaccine can not completely cover the 7 serotypes reported.Vasculitis mainly occurs in the thoracic and abdominal aorta and its branches, middle cerebral artery and so on.Of the 8 cases of hemophagocytic syndrome, 2 cases died.Early anti-infection, methylprednisolone shock and surgical treatment can improve the prognosis.Vaccination and drug prophylaxis can help those with under-lying diseases such as splenic dysfunction to reduce the incidence of SPD, such as SP-OPSI.
