Nasal cytology with emphasis on mast cells can improve the diagnosis and treatment of chronic rhinosinusitis
10.1097/CM9.0000000000000387
- Author:
Hua-Li REN
1
;
Jian-Dong LI
2
;
Feng-Shu YUE
2
;
Jin-Lu SUN
3
;
Elie E. REBEIZ
4
;
Theoharis C. THEOHARIDES
5
Author Information
1. Department of Allergy, Beijing Electric Power Hospital, Beijing 100073, China
2. Department of Otolaryngology, Beijing Electric Power Hospital, Beijing 100073, China
3. Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
4. Department of Otolaryngology, Tufts Medical Center, Boston, MA 02111, USA
5. Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111, USA;Sackler School of Graduate Biomedical Sciences, Program in Pharmacology and Experimental Therapeutics, Tufts University, Boston, MA 02153, USA;Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, MA 02111, USA
- Publication Type:Review
- Keywords:
Rhinitis;
Sinusitis;
Nasal polyps;
Nasal mucosa;
Cytology;
Inflammation;
Eosinophils;
Mast cells
- From:
Chinese Medical Journal
2019;132(18):2237-2241
- CountryChina
- Language:English
-
Abstract:
Objective:Chronic rhinosinusitis (CRS) involves inflammation of the nasal and para-nasal mucosa. Due to its heterogeneous nature, unknown pathogenesis, and high recurrence rate, effective treatment is difficult. Nasal cytology is presently not a part of the routine diagnosis or treatment decision for CRS.
Data sources:A literature search was performed for published papers in English between January 1990 and June 2019 using MEDLINE.
Study selection:Terms used were chronic rhinosinusitis, eosinophils, etiology, immunopathology, inflammation, mast cells, nasal cytology, polyps, and treatment. Both reviews and original articles were collected and studied.
Results:There is no standard nasal fluid, mucus sampling, or staining techniques for identifying inflammatory cell types. Results were divergent from different countries. Moreover, the main focus of these papers on the cells in nasal washings was eosinophils, with infrequent mentioning of other cell types that may imply different etiology and pathology. The heterogeneous cell profile of CRS and the role of mast cells have been unappreciated due to the lack of specific immunohistochemical technique or study of its unique mediators.
Conclusions:Nasal cytology could help distinguish the type and the activation state of inflammatory cells. Thus it can help in providing a clearer picture of CRS pathogenesis, identifying different patient groups, and developing effective treatments.
