Effects of Shenyankangfu tablets combined with losartan on cellular immune function, inflammatory factors and renal function in patients with chronic glomerulonephritis
10.3760/cma.j.issn.1008-6706.2019.16.016
- VernacularTitle: 肾炎康复片联合氯沙坦对慢性肾小球肾炎患者细胞免疫功能、炎性因子和肾功能的影响
- Author:
Fang FANG
1
Author Information
1. Department of Nephrology, Da Jiangdong Hospital, Hangzhou, Zhejiang 311225, China
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Cellular immune function;
Inflammatory factors;
Renal function;
Nephritis rehabilitation tablets;
Losartan
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(16):1986-1989
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Shenyankangfu tablets combined with losartan on cellular immune function, inflammatory factors and renal function in patients with chronic glomerulonephritis.
Methods:From March 2017 to March 2018, 94 patients with chronic glomerulonephritis admitted to Hangzhou Dajiangdong Hospital were randomly divided into observation group (47 cases) and control group (47 cases). The control group was treated with losartan, and the observation group was treated with Shenyankangfu tablets on the basis of the control group.The two groups were treated for 12 weeks.The changes of cellular immune function, inflammatory factors and renal function were compared between the two groups before and after treatment.
Results:After treatment, the levels of CD4＋(71.98±3.28)%, CD4＋(40.01±3.86)% and CD4＋/CD8＋ (1.54±0.23) in the observation group were higher than those in the control group [(64.32±4.01)%, (34.87±1.96)% and (1.23±0.16)] (t=10.137, 8.140, 7.585, all P<0.05). After treatment, the level of IL-2 in the observation group [(3.18±0.59)μg/L] was higher than that in the control group [(2.37±0.71)μg/L], while the levels of IL-6[(227.42±12.41)ng/L] and TNF-α [(2.45±0.29)ng/L] in the observation group were lower than those in the control group [(289.64±19.36)ng/L and (3.38±0.65) ng/L] (t=6.015, 18.549, 8.958, all P<0.05). After treatment, the levels of Scr [(123.49±8.97)μmol/L], Upro[(0.76±0.18)g/24h] and BUN[(6.71±0.5)mmol/L] in the observation group were lower than those in the control group [(159.51±7.41)μmol/L, (1.28±0.23)g/24h, (7.91±0.47)mmol/L](t=21.224, 12.206, 11.136, all P<0.05). The total effective rate of the observation group (93.62%) was higher than that of the control group (72.34%) (P<0.05).
Conclusion:Shenyankangfu tablets combined with losartan can improve the cellular immune function and renal function in patients with chronic glomerulonephritis, and can reduce inflammatory reaction.The curative effect is remarkable, which is worthy of clinical reference.
