Clinical value of combined detection of serum CEA, CA199, CA125 in the diagnosis of lung cancer
10.3760/cma.j.issn.1008-6706.2019.13.015
- VernacularTitle: 血清癌胚抗原、糖类抗原199、糖类抗原125联合检测在肺癌中的诊断价值
- Author:
Pengfei REN
1
;
Yong ZHAO
2
Author Information
1. Department of Emergency Medicine, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui 236000, China
2. Department of Emergency Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Carcinoembryonic antigen;
Antigens, tumor-associated, carbohydrate;
Tumor markers, biological;
Sensitivity;
Specificity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(13):1596-1599
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic value of combined detection of carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199) and carbohydrate antigen 125 (CA125) in lung cancer.
Methods:From July 2017 to February 2019, 64 patients with lung cancer, 40 cases of benign pulmonary lesions and 40 healthy people were selected by random lottery in Fuyang Hospital Affiliated to Anhui Medical University.Serum CEA, CA199 and CA125 levels of each group were analyzed.
Results:The levels of serum CEA, CA199 and CA125 in patients with lung cancer were significantly higher than those in patients with benign lung disease, the differences were statistically significant (t=18.355, P<0.001; t=11.757, P<0.001; t=10.754, P<0.001). The serum CA125 of lung benign disease group was significantly higher than the healthy group, and the difference was statistically significant(t=6.942, P<0.001). The positive rates of serum CEA, CA199 and CA125 in patients with lung cancer were significantly higher than those in the benign lung disease group and healthy group, the differences were statistically significant(χ2=22.110, P<0.001; χ2=13.321, P=0.002; χ2=15.125, P=0.001). The serum levels of CEA, CA199, and CA125 in patients with middle and advanced stage were significantly higher than those in the early stage, the differences between the advanced group and the early group were statistically significant (t=5.587, P<0.001; t=5.068, P<0.001; t=8.962, P<0.001). Those between the mid-term group and the early group had statistically significant differences (t=4.44, P<0.001; t=4.716, P<0.001; t=12.700, P<0.001). The CEA level of patients with advanced lung cancer was significantly higher than that of the intermediate patients.There was statistically significant difference in the CEA level between the advanced group and the mid-term group (t=3.860, P=0.001). Serum CA125 was the most sensitive in the diagnosis of lung cancer (60.84%), but had the lowest specificity (65.17%). CA125 compared with CA199, CEA, the difference was statistically significant (sensitivity: χ2=10.723, P<0.001 specificity: χ2=4.203, P=0.023). The sensitivity of CEA+ CA199+ CA125 combined detection was significantly higher than single detection, the difference was statistically significant(χ2=26.047, P<0.001),
Conclusion:The combined detection of serum CEA, CA125 and CA199 has high sensitivity in the diagnosis of lung cancer, which can improve the detection rate of early lung cancer and is worthy of clinical application.
