Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation
10.13422/j.cnki.syfjx.20190427
- VernacularTitle: 独活续断汤对不同类型腰间盘突出症患者临床疗效、生活能力的影响及机制
- Author:
Zhi-guang WANG
1
;
Yan-hui SHANG
2
;
Tao TAN
1
;
Bing RONG
1
Author Information
1. The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(TCM), Tianjin 300193, China
2. Wuqing TCM Hospital Affiliated to Tianjin University of TCM, Tianjin 301700, China
- Publication Type:Research Article
- Keywords:
lumbar disc herniation;
Duhuo Xuduan Tang;
bone morphogenetic protein-7;
aggrecan;
pain factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(4):63-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate clinical efficacy of Duhuo Xuduan Tang in treatment of lumbar disc herniation with different syndrome types and its effect on serum pain factors, bone morphogenetic protein-7 (BMP-7) and Aggrecan. Method: A total of 121 patients with non-emergency lumbar disc herniation admitted to the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from January 2017 to June 2018 were randomly divided into observation group (62 cases) and control group (59 cases). The two groups of patients were treated by repositioning maneuver before absolute bed rest. observation group was given Duhuo Xuduan Tang, 150 mL·time-1, 3 times·d-1 orally, while control group was orally given ibuprofen, 300 mg·time-1, vitamin B1, 10 mg·time-1, 2 times·d-1, drugs were taken for 5 days a week, and then stopped for 2 days. Both groups were treated continuously for 4 weeks. changes in visual analogue score (VAS), modified Oswestry dysfunction index (MODI), serum substance P (SP), dopamine (DA), serotonin (5-HT), BMP-7 and Aggrecan were observed before and after treatment with enzyme-linked immunosandwich assay (ELISA). Result: Compared with before treatment, VAS and modified Oswestry dysfunction index scores were lower in both groups (P<0.05), BMP-7 and Aggrecan contents were higher, while SP, DA and 5-HT contents were lower (P<0.05). Compared with control group, VAS and modified Oswestry dysfunction index scores of observation group were lower (P<0.05), clinical efficacy was improved (P<0.05), levels of BMP-7 and Aggrecan in serum were higher, whereas contents of SP, DA and 5-HT were lower (P<0.05). Conclusion: Duhuo Xuduan Tang has a certain efficacy on different types of lumbar disc herniation, with best efficacy for patients with liver and kidney yin deficiency.
