Molecular Mechanism of Anti-thrombosis and Anti-platelet Aggregation of Sparganii Rhizoma Based on Integrated Pharmacological Platform
10.13422/j.cnki.syfjx.20182111
- VernacularTitle: 基于整合药理学平台探究三棱抗血栓形成及抗血小板聚集的分子机制
- Author:
Nan XU
1
;
Liang WANG
1
;
Rong SUN
2
;
Xin HUANG
3
;
Cheng-bo ZHANG
4
;
Hai-yan SHI
3
Author Information
1. Shandong Academy of Chinese Medicine, Ji'nan 250014, China
2. Institute of Advanced Medical Sciences, Shandong University, Ji'nan 250012, China
3. Shandong Provincial Qianfoshan Hospital, Ji'nan 250014, China
4. Postdoctoral Mobile Station of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China
- Publication Type:Research Article
- Keywords:
Sparganii Rhizoma;
thrombosis;
platelet aggregation;
integrated pharmacology;
mechanism;
key pathways;
key targets
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(5):192-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study on the molecular mechanism of anti-platelet aggregation and anti-thrombosis of Sparganii Rhizoma. Method: Based on the data information and analysis functions of traditional Chinese medicine(TCM) database,TCM composition database and target database in TCM platform for integration of pharmacology,information of chemical compositions in Sparganii Rhizoma was retrieved,interaction network between potential targets of Sparganii Rhizoma and disease targets was built,and the key targets were enriched and calculated,the gene functions and pathways were analyzed,multidimensional relationship network of " herbal medicines-chemical components-key targets-key pathways" was built. Result: Active ingredients of Sparganii Rhizoma mainly included flavonoids and phenolic acids,such as mountain kaempferol,sanleng acid,linoleic acid,etc.Anti-thrombosis involved 202 key targets,including protein kinase Cδ(PRKCD),glucose kinase(GCK),(PRKAA2),adenosine ribonucleotide activated protein kinase α-2 catalytic subunit,etc;and it was related to the endocrine system,circulatory system,neurodegenerative diseases and other related biological processes and signal pathways.Anti-platelet aggregation involved 136 key targets,including PRKCD,cytochrome C oxidase protein 7C(COX7C),GCK,etc;and it was involved in Parkinson's disease,circulatory system,neurodegenerative diseases and other related biological processes and signal pathways. Conclusion: Sparganii Rhizoma regulates vascular endothelial cell adhesion molecule expression and platelet mitochondrial function mediated apoptosis of platelets mainly through regulating neurotransmitter activity in the central nervous system,in order to exert antithrombotic effect and anti-platelet aggregation effect.
