Effect of Modified Renseng Yangrong Tang Combined with Chemotherapy on Serum Tumor Markers and Th1/Th2-type Cytokines Expression in Cervical Cancer Patients
10.13422/j.cnki.syfjx.20182426
- VernacularTitle: 加味人参养荣汤联合化疗对宫颈癌患者血清肿瘤标志物,Th1/Th2型细胞因子表达水平的影响
- Author:
Li-fang WEN
1
;
Jie DING
2
Author Information
1. Shanxi Fenyang College, Fenyang 032200, China
2. Shanxi Fenyang Hospital, Fenyang 032200, China
- Publication Type:Research Article
- Keywords:
cervical cancer;
modified Renseng Yangrong Tang;
serum tumor markers;
Th1/Th2 cytokines;
adverse reactions
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(5):68-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of modified Renseng Yangrong Tang combined with chemotherapy on serum tumor markers and Th1/Th2 type cytokines expression in cervical cancer patients. Method: A total of 114 patients with cervical cancer admitted in our hospital from December 2014 to December 2017 were selected as the study subjects. According to the random number table method, the patients were divided into two groups. The control group (57 cases) was treated with conventional chemotherapy. The treatment group (57 cases) was treated with modified Renseng Yangrong Tang in addition to the conventional chemotherapy. Traditional Chinese medicine (TCM) symptom scores, serum tumor markers[carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCA), carbohydrate antigen 125 (CA125)]and Th1/Th2 type cytokine[interferon gamma-interferon (IFN-γ), interleukin-4 (IL-4), interleukin-2 (IL-2), interleukin-6 (IL-6) levels], clinical efficacy after treatment 3 months, and adverse reaction rate of two groups were observed. Result: There was no significant difference in TCM symptom scores, serum tumor markers and Th1/Th2 cytokines between the two groups before treatment. After treatment, the TCM symptom scores, CEA, SCCA, CA125, IL-6, and IL-4 levels in the treatment group were lower than those in control group and before treatment (P<0.05). The levels of IL-2 and IFN-γ were higher than those in the control group and before treatment (P<0.05). The patients in treatment group were significantly better than those in control group in terms of physical function, mental health, overall health, body pain, social function and vitality (P<0.05), but there was no significant difference in physical role and emotional role. The total effective rate of treatment group (82.46%) was higher than that of control group (64.91%), and the adverse reaction rate (14.04%) was lower than control group (29.82%). The difference was statistically significant (χ2=4.524, 4.150, P<0.05). Conclusion: Modified Renseng Yangrong Tang can significantly relieve clinical symptoms, reduce the level of serum tumor markers, improve cellular immunity, improve the recent therapeutic effect, and reduce adverse reactions in patients with cervical cancer chemotherapy.
