Antidiarrheal Effect of Limonitum with Different Mineral Genesis
10.13422/j.cnki.syfjx.20190524
- VernacularTitle: 不同矿物成因禹余粮的止泻作用
- Author:
Yu-lu MA
1
;
Sheng-jin LIU
1
;
Fang FANG
1
;
Yu-hua WANG
1
;
Wen-guo YANG
1
;
Rui-chao LIN
2
;
De-kang WU
1
;
Chao-ying WU
1
Author Information
1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicine Resource Recycling Utilization, Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. Beijing University of Chinese Medicine, Beijing 100029, China
- Publication Type:Research Article
- Keywords:
mineral Chinese medicine;
Limonitum;
diarrhea;
antidiarrheal;
castor oil;
contraction of ileum
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(5):21-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antidiarrheal effect and the gastrointestinal motility of two kinds of Limonitum with different mineral genesis, so as to select the optimal mineral genesis, and provide a theoretical basis for clinical use. Method: The selected research samples were leaching type and sedimentary type Limonitum with different mineral genesis, including powder, water decoction and dregs. In the experiment, castor oil (0.2 mL/10 g) was used to induce diarrhea, loperamide (4 mg·kg-1) was used for positive control, and then the antidiarrheal activity and the gastrointestinal motility were observed. Result: In the castor oil-induced diarrhea experiment, the diarrhea index of the water decoction (2.5,5,10 g·kg-1) and the dregs (2.5 g·kg-1) of leaching type Limonitum significantly reduced (P<0.05), and so did the degree of diarrhea in mice; the powder of sedimentary type Limonitum, the powder (10 g·kg-1) of leaching type limonitum and the dregs (2.5,5,10 g·kg-1) of the leaching type Limonitum were significant different at the first defecation (P<0.05); the powder (5 g·kg-1) and the water decoction (2.5 g·kg-1) of leaching type Limonitum, and the total feces weight of the mice were significantly decreased (P<0.05). In the gastrointes motility experiment, the water decoction (5 g·kg-1), the dregs (2.5,5,10 g·kg-1) of the sedimentary, the powder (2.5,5 g·kg-1), the water decoction (2.5,5,10 g·kg-1) and the dregs (10 g·kg-1) of leaching type Limonitum were significantly lower than those of the model group on the intestinal motility, with charcoal as a marker (P<0.05);the dregs (10 g·kg-1) of leaching type Limonitum was significantly higher than that of the model group on the content of small intestine contents (P<0.05); the water decoction (10 g·kg-1) of sedimentary type limonitum, and the water decoction (2.5,5 g·kg-1) of leaching type Limonitum were significantly lower than those of the model group on gastric residual rate (P<0.05); the powder (5 g·kg-1), the dregs (5 g·kg-1) of sedimentary type Limonitum were significantly reduced on the water content of large intestine compared with the model group (P<0.05). The 0.003 3,0.006 7,0.013 3 g·mL-1 of Limonitum can inhibit the contraction of isolated ileum induced by acetylcholine in rabbits except 0.003 3 g·mL-1 water decoction of leaching type. Conclusion: Mineral medicine Limonitum has a certain therapeutic effect in castor oil-induced diarrhea. Leaching type limonitum has the best antidiarrheal effect.
