Exploring Potential Mechanism of “Fu Zheng” Rule of Ulcerative Colitis Based on Network Pharmacology
10.13422/j.cnki.syfjx.20191541
- VernacularTitle: 基于网络药理学挖掘溃疡性结肠炎“扶正”治则的潜在机制
- Author:
Bing-yu CHEN
1
;
Ke LIU
2
;
Fei GE
3
;
Zhi-guang SUN
1
Author Information
1. The Second Affiliated Hospital of Nanjing University of Traditional Chinese Medicine(TCM), Nanjing 210000, China
2. Zhengzhou People's Hospital, Zhengzhou 450000, China
3. Hai'an Hospital of TCM, Hai'an 226600, China
- Publication Type:Research Article
- Keywords:
network pharmacology;
ulcerative colitis;
Fuzheng rule;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(15):191-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Through database search and network pharmacology to explore the potential mechanism of "Fu Zheng" rule of ulcerative colitis. Method:Search for ulcerative colitis related prescriptions from the Chinese medicine E database, Screening the retrieved prescriptions and conducting statistical analysis of the types and frequency of drugs, and selecting the objective drugs for the treatment of ulcerative colitis. Search for the chemical composition and target of drugs on the Digsee platform, then constructing a compound-target interaction network map. Screening for ulcerative colitis related targets through the Digsee database and construct a disease-target interaction network map. Filter the core targets of the two network maps and using the DAVID tool to perform enrichment analysis on the core targets. Result:About 731 prescriptions of ulcerative colitis were retrieved from the database, 304 prescriptions and 220 Chinese medicines were received based on the inclusion and exclusion criteria. Representative drugs of "Fu Zheng" Rule of ulcerative colitis is Glycyrrhizae Radix et Rhizoma, Ginseng Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma. Screening for chemical constituents of the drug based on ADME parameters, and then target prediction, we received a total of 137 protein targets. Merge the compound-target interaction network map and the disease-target interaction network map, with "Degree" "betweenness " and "closeness" as the evaluation criteria, we found 129 common targets. Perform KEGG enrichment analysis on the selected targets, find out the top 20 pathways with P values has an effect on ulcerative colitis. Conclusion:The role of FuZheng Chinese medicine in the treatment of ulcerative colitis is the overall effect of multiple targets and multiple pathways, excavating the potential mechanism of "Fu Zheng" rule of ulcerative colitis and provide a theoretical basis for further experimental research.
