Clinical Efficacy of Modified Shaofu Zhuyutang Combined with Zhengs Rebuzhen Therapy on Pain Caused by Adenomyosis
10.13422/j.cnki.syfjx.20191235
- VernacularTitle: 少腹逐瘀汤加减联合郑氏“热补针法”治疗子宫腺肌病相关疼痛的临床观察
- Author:
Hai-xia DING
1
;
Feng-di PENG
2
;
Xiao-hua ZHANG
2
;
Yu-quan WANG
3
Author Information
1. The Affiliated Hospital of Gansu University of Traditional Chinese Medicine(TCM), Lanzhou 730020, China
2. The Clinical College of TCM, Gansu University of TCM, Lanzhou 730000, China
3. Gansu Provincial Chinese Medicine Hospital, Lanzhou 730050, China
- Publication Type:Research Article
- Keywords:
adenomyosis;
cold coagulation and blood stasis syndrome;
Zheng's Rebuzhen therapy;
Shaofu Zhuyutang;
pain
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(15):142-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of modified Shaofu Zhuyutang combined with Zheng's Rebuzhen therapy on pain caused by adenomyosis (cold coagulation and blood stasis syndrome) and levels of vascular endothelial growth factor (VEGF), matrix metalloproteinases-9 (MMP-9), tissue inhibitors of matrix metalloproteinases (TIMP-1) and prostaglandin. Method:One hundred and twenty-eight patients were randomly divided into control group (63 cases) and observation group (65 cases) by random number table. Patients in control group got desogestrel and ethinylestradiol tablets since the first day of menstruation for consecutive 21 days, 1 granule/time, 1 time/day, and Zheng's Rebuzhen therapy for consecutive 10 days during the menstruation, 1 time/day. In addition to the therapy of control group, patients in observation group were also given Shaofu Zhuyutang, 1 dose/day. A course of treatment was 3 menstrual cycles. Before and after treatment, cox menstrual symptom scale (CMSS) of COX, visual simulation of dysmenorrheal (VAS), chronic pelvic pain, pictorial blood loss assessment chart (PBAC) and cold coagulation and blood stasis syndrome were scored. And uterine volume and endometrial thickness were evaluated by B-mode ultrasonography. And levels of VEGF, MMP-9, TIMP-1, prostaglandin E2 (PGE2), prostaglandin F2α(PGF2α) and cancer antigen were detected. Result:After treatment, the clinical efficacy in observation group was superior to that in control group (Z=2.445, P<0.05). After treatment, scores of VAS, dysmenorrhea time of COX, dysmenorrheal of COX, chronic pelvic pain, PBAC and cold coagulation and blood stasis syndrome were lower than those in control group (P<0.01). And uterine volume and endometrial thickness were lower than those in control group (P<0.01). And levels of VEGF, MMP-9, MMP-9/TIMP-1, PGF2α and CA125 were lower than those in control group (P<0.01), while levels of TIMP-1 and PGE2 were higher than those in control group (P<0.01). Conclusion:In addition to desogestrel and ethinylestradiol tablets combined with Zheng's Rebuzhen therapy, modified Shaofu Zhuyutang can relieve pain and hemorrhage and improve the clinical efficacy. The mechanism may be correlated with the regulation of expression levels of VEGF, MMP-9, TIMP-1 and prostaglandin.
