Network Pharmacology of Polygalae Radix and Gastrodiae Rhizoma in Treating Epilepsy
10.13422/j.cnki.syfjx.20191306
- VernacularTitle: 远志-天麻药对治疗癫痫的网络药理学分析
- Author:
Ze-feng ZHAO
1
;
Xu-fei CHEN
1
;
Jing XIE
1
;
Bin LI
1
;
Xi-rui HE
1
;
Xiao-hui ZHENG
1
Author Information
1. Key Laboratory of Resource Biology and Biotechnology in Western China Under Ministry of Education, Northwest University, Xi'an 710069, China
- Publication Type:Research Article
- Keywords:
Polygalae Radix;
Gastrodiae Rhizoma;
antiepilepsy;
network pharmacology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(14):207-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To construct a "drug-target-pathway" network of Polygalae Radix and Gastrodiae Rhizoma in treating epilepsy, in order to explore the "multi-component, multi-target, multi-pathway" mechanism of the two kinds of traditional Chinese medicines. Method:According to the reverse pharmacophore matching method, potential targets of Polygalae Radix and Gastrodiae Rhizoma were predicted. Biological information annotation databases were used to analyze the molecular function and biological process of the action targets. Cytoscape 3.2.1 software was used to construct the "ingredient-core, target-pathway" network of Polygalae Radix and Gastrodiae Rhizoma for the treatment of epilepsy. Result:The 14 major constituents from Polygalae Radix exhibited interactions with 105 potential targets, and the 12 compounds from Gastrodiae Rhizoma showed interactions with 109 potential targets, involving several cancer signaling pathways, neuroactive ligand-receptor interaction and mitogen-activated protein kinase(MAPK) biological process played roles in the treatment of epilepsy. Conclusion:According to the screening for the potential targets relating to epilepsy and the evidences obtaining from docking study, we demonstrated that constituents from Polygalae Radix and Gastrodiae Rhizoma could play an anticonvulsant role by mediating the levels of monoamine substances. The conclusion is close to literatures published online to a certain degree, suggesting the accuracy of the study on the effect of Polygalae Radix and Gastrodiae Rhizoma in treating epilepsy according to the network pharmacology.
