Clinical Efficacy of Yang Warming, Stasis Dissipating and Detoxifying Method on Sepsis-induced Myocardial Dysfunction
10.13422/j.cnki.syfjx.20191132
- VernacularTitle: 温阳化瘀解毒法治疗脓毒症心功能障碍的临床观察
- Author:
Yan DONG
1
;
Xu DONG
1
;
Pan-pan YU
2
;
Bao-zhu SHI
1
Author Information
1. Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China
2. Hebei Medical University, Shijiazhuang 050011, China
- Publication Type:Research Article
- Keywords:
sepsis-induced myocardial dysfunction;
Shengma Biejia Tang;
Shenfutang;
yang warming, stasis dissipating and detoxifying;
inflammatory reaction
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(14):125-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe clinical efficacy of Shengma Biejia Tang combined with Shenfutang on sepsis-induced myocardial dysfunction (SIMD) and study the controlling effect on inflammatory reaction. Method:Eighty-eight patients with SIMD were randomly divided into control group (44 cases) and observation group (44 cases) by random number table. Patients in control group received the early bundle therapy of sepsis, including fluid resuscitation, anti-infection treatment and vasoactive drugs. In addition to the therapy of control group, patients in observation were also given Shengma Biejia Tang combined with Shenfutang, 1 dose/day. And a course of treatment was 7 days. Before and after treatment, levels of troponin (cTnI), creatine kinase isoenzyme (CK-MB), N terminal brain natriuretic precursor (NT-proBNP), calcitonin (PCT), hypersensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukins-6 (IL-6) and blood lactic acid (LAC) were detected. And color Doppler ultrasound examination of the heart was performed to record left ventricular ejection fraction (LVEF), blood flow velocity of early mitral valve diastole and ratio of blood flow velocity at atrial systolic peak (E/A) and stroke volume (SV). And lactate clearance rate (LCR) was calculated. And sequential (sepsis-related) organ failure assessment (SOFA), acute physiology and chronic health (APACHEⅡ) and traditional Chinese medicine(TCM)syndromes were scored. Result:After treatment, levels of cTnI, NT-ProBNP, CK-MB, Hs-CRP, IL-6, PCT, TNF-α and LAC in observation group were lower than those in control group (P<0.01), and levels of LVEF, E/A, SV and LCR were higher than those in observation group (P<0.01). And scores of SOFA, APACHEⅡ and traditional Chinese inedicine(TCM) syndromes were lower than those in control group (P<0.01). Conclusion:In addition to the integrated western medicine, Shengma Biejia Tang combined with Shenfutang can control inflammatory reaction, relieve myocardial inhibition and myocardial damage, and protect and improve heart function, and alleviate the symptoms.
