Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β1 in Serum of Senile Asthma on Persistent Stage
10.13422/j.cnki.syfjx.20191423
- VernacularTitle: 金水六君煎加味联合沙美特罗替卡松粉吸入剂对慢性持续期老年哮喘患者血清VEGF,TGF-β1的影响
- Author:
Lin JIA
1
;
Bo-lin LI
1
;
Li-ying WEI
1
;
Xuan ZHANG
1
;
Lei WU
1
Author Information
1. Hebei Province Hospital of Traditional Chinese Medicine, Shijiazhuang 050031, China
- Publication Type:Research Article
- Keywords:
modified Jinshui Liujunjian;
senile asthma;
vascular endothelial growth factor (VEGF);
transforming growth factor-β1 (TGF-β1);
clinical observation;
Chinese traditional treatment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(14):119-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy of modified Jinshui Liujunjian combined with salmeterol/fluticasone on senile asthma on persistent stage and its effect on vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) in serum. Method:The 100 cases of senile asthma who met inclusion criteria were selected and divided into two equal groups by random number table:the control group and the treatment group. Patients of the two groups were given oxygen therapy,phlegm reduction,infection control and salmeterol/fluticasone 50 μg·(500 μg)-1. Patients in control group were given sustained release capsule of theophylline in addition to the above therapy,while patients in treatment group were given modified Jinshui Liujunjian. The course of treatment was 8 weeks. The therapeutic effectiveness of traditional Chinese medicine (TCM) syndrome between two groups was observed. Asthma control test (ACT) scores at four different time points(before and after treatment,3, 6 months after treatment),pulmonary function,the levels of VEGF and TGF-β1 in serum before and after treatment between two groups were also observed. The pharmic safety during treatment was evaluated. Result:The total effective rate of treatment group was significantly higher than that of control group(P<0.05). Compared with that in control group,ACT scores in treatment group were significantly higher at three different time points(after treatment,3 and 6 months after treatment) (P<0.05). Compared with that in control group,peak expiratory flow (PEF) variability and the levels of VEGF and TGF-β1 in serum in treatment group were significantly lowered after treatment(P<0.05),while the percentage of forced expiratory volume in the first second and its predicted value (FEV1%), and the percentage of forced expiratory volume in the first second and its forced vital capacity (FEV1/FVC) were significantly higher(P<0.05). Compared with that in control group,the incidence of the untoward effect in treatment group were significantly lowered during treatment(P<0.05). Conclusion:Modified Jinshui Liujunjian combined with Salmeterol/Fluticasone was more effective than Sustained release capsule of theophylline combined with Salmeterol/Fluticasone in improving the clinical efficacy and pulmonary function of senile asthma on the persistent stage. Its mechanism of action is probable correlated with the reduction of levels of VEGF and TGF-β1 in serum.
