Efficacy of Jianpi Shugan Fomula on Intestinal Flora of Patients with Diarrhea Predominant Irritable Bowel Syndrome and Its Effect on Intestinal Flora
10.13422/j.cnki.syfjx.20191224
- VernacularTitle: 健脾疏肝法对腹泻型肠易激综合征患者疗效观察及对肠道菌群的影响
- Author:
Xing-xing ZHANG
1
;
Jian WU
1
;
Li-xia PEI
1
;
Yi XU
1
;
Bai YE
1
;
Shen-lin LIU
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
- Publication Type:Research Article
- Keywords:
Jianpi Shugan decoction;
acupuncture;
diarrhea-type irritable bowel syndrome;
liver depression and spleen deficiency;
intestinal flora;
Tongxie Yaofang;
Shenqi Baizhu San;
Xianglian Wan
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(13):79-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Jianpi Shugan decoction combined with acupuncture on the clinical symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency and the intestinal flora. Method:Seventy patients with IBS-D with liver depression and spleen deficiency were randomly divided into two groups by the random number table. The treatment group was given Jianpi Shugan decoction combined with acupuncture for 4 weeks, the control group was treated with Pivavironium bromide for 4 weeks, and 30 healthy people were used as healthy control. The total effective rate, IBS bowel symptom severity scale (IBS-BSS), IBS quality of life questionnaire (IBS-QOL) and traditional Chinese medicine pattern curative effect scoring system (TCM-PES) were evaluated. The counts of Bacillus bifidus, B.acidi lactici, Enterobacteria, and Bacteroides in feces and the colonization resistance (CR) were observed by Real-time PCR. Result:The IBS-SSS scale showed that the TCM treatment group could reduce the scores at the 4th, 8th, and 12th weeks (P<0.05), and the control group could reduce the scores at 4th and 8th weeks (P<0.05), the 4th week scores of TCM treatment group were better than that of control group (P<0.05). The total effective rate of TCM treatment group was better than that of control group, with statistical difference between two groups (P<0.05). The IBS-QOL scale showed that the TCM treatment group increased the scale scores at the 4th, 8th, and 12th weeks, and the control group increased the scores at the 4th week (P<0.05). There was no statistical difference between two groups. The TCM treatment group was superior to control group (P<0.05). The counts of B.bifidus and B.acidi lactici increased after 4 weeks of TCM treatment, and the count of Enterobacteria decreased (P<0.05). However, no obvious change was observed in patients of control group before and after treatment. Compared with the control group, B. bifidus increased, while Enterobacteria decreased in the TCM treatment group (P<0.05). There was no significant regulatory effect of Bacteroides after treatment in each group. Conclusion:Jianpi Shugan decoction combined with acupuncture has a reliable curative effect on IBS-D patients with liver depression and spleen deficiency. The mechanism may be related to the regulation of intestinal flora imbalance.
