Research Progress of Astragali Radix and Salviae Miltiorrhizae Radix on Improving Renal Damage in Hypertension
10.13422/j.cnki.syfjx.20191105
- VernacularTitle: 黄芪-丹参药对改善高血压肾损害的研究进展
- Author:
Cong HAN
1
;
Yue-hua JIANG
2
;
Wei LI
2
Author Information
1. First Clinical Medical School, Shandong University of Traditional Chinese Medicine(TCM), Ji'nan 250014, China
2. Affiliated Hospital of Shandong University of TCM, Ji'nan 250014, China
- Publication Type:Research Article
- Keywords:
Astragali Radix-Salviae Miltiorrhizae Radix;
hypertensive renal damage;
lowering blood pressure;
improve kidney function.
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(12):214-220
- CountryChina
- Language:Chinese
-
Abstract:
Hypertensive renal damage is one of the most serious complications of hypertension, and it is also the main cause of end-stage renal disease. Renal damage can further promote the rise of blood pressure and difficult to control, forming a vicious circle. Traditional Chinese medicine (TCM) considers that deficiency of the original and excess of the standard is its basic pathogenesis, and insufficient kidney-Qi and blood stasis are one of the most common syndromes of hypertensive kidney damage. Astragali Radix membranaceus is praised as the most important medicine for invigorating Qi, and Salviae Miltiorrhizae Radix is likened to "four things with the same function". Based on the theory of invigorating Qi and activating blood circulation, the effective ingredients of Astragali Radix membranaceus-Salviae Miltiorrhizae Radix are mainly astragaloside, Astragali Radix polysaccharide, mulberry isoflavone, salvianolic acid and tanshinone. Many studies have shown that in the process of hypertensive kidney damage, Astragali Radix membranaceu Its active ingredients, whether effective monomers, monomer compatibility or direct compatibility of drug pairs, can regulate blood pressure, reduce urinary protein, protect renal tubules, protect glomerular filtration barrier, improve renal hemodynamics and protect renal function by regulating multiple signal transduction pathways related to hypertensive renal damage. Lowering blood pressure and protecting renal function are two pronged functions. Based on the theory of Invigorating Qi and activating blood circulation, this paper reviews the research progress of Astragali Radix-Salviae Miltiorrhizae Radix in the treatment of hypertensive renal damage, with a view to providing scientific basis for the further study and clinical application of Radix astragali-Salviae Miltiorrhizae Radix in hypertensive renal damage.
