Effect of Modfied Yinchen Wuling San in Treating Non-alcoholic Fatty Liver Disease with Moisture and Heat Implication and on Intestinal Microflora
10.13422/j.cnki.syfjx.201901232
- VernacularTitle: 加味茵陈五苓散治疗湿热蕴结型非酒精性脂肪性肝病的疗效及对肠道菌群的影响
- Author:
Li XU
1
;
Jing FU
1
;
Fang FANG
1
;
Liang-zhen CHEN
1
;
Gui-feng ZHUANG
1
Author Information
1. The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver;
moisture and heat implication;
Yinchen Wuling San;
intestinal microflora
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(12):127-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of modified Yinchen Wuling San in treating liver function and blood lipid of non-alcoholic fatty liver disease (NALFD) with moisture and heat implication and the mechanism on intestinal microflora. Method: One hundred and thirteen patients were randomly divided into control group (57 cases) and observation group (56 cases) by random number table according to SAS. Both groups'patients got non drug intervention. Patients in control group got polyene phosphatidylcholine capsules, 2 grains/time, 3 times/days, and live combined Bacillus subtilis and Enterococcus faecium Enteric-coated capsules, 2 grains/time, 3 times/days. In addition to therapy of control group, patients in observation was also given modified Yinchen Wuling San, 1 dose/day. The treatment in two groups continued for 12 weeks. Before and after treatment, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and intestinal microflora were detected. And CT and B-mode ultrasonography of abdomen were detected. And traditional Chinese medicine (TCM) syndromes were scored. Result: After treatment, levels of ALT and AST in observation group were lower than those in control group (Z=2.002, P<0.05), and score of TCM symptoms were lower than those in control group, whereas level of CT liver/spleen was higher than that in control group (P<0.01). And effect of laboratory indicators was better than that in control group (Z=1.955, P<0.05), CT was better than that in control group (Z=2.002, P<0.05), and B-mode ultrasonography of abdomen was better than that in control group (Z=1.961, P<0.05). Compared with healthy control group, enterobacteriaceae, staphylococcus of patients in two groups increased, while bacteroid, bacillus bifidus and bacillus lactis decreased (P<0.01). After treatment, enterobacteriaceae, staphylococcus in observation group were lower than those in control group, whereas bacteroid, bacillus bifidus and bacillus lactis were higher than those in control group (P<0.01). Conclusion: Modified Yinchen Wuling San can protect liver function of NAFLD, regulate lipid metabolism, ameliorate intestinal microflora, and recover the ecological equilibrium of intestine, with a good clinical effect.
