Influence of Addition and Subtraction Therapy of Guyinjian to Ovarian Reserve Function for Patients with Poor Ovarian Response with Kidney Yin Deficiency Syndrome
10.13422/j.cnki.syfjx.20191032
- VernacularTitle: 固阴煎加减对育龄期卵巢低反应肾阴虚型患者卵巢储备功能的影响
- Author:
Ying-qun LIU
1
;
Ying ZHOU
1
;
Xiao-cui ZHANG
1
;
Xuan ZENG
2
;
Ling-yan CHEN
2
;
Xuan LI
3
Author Information
1. Shangrao People's Hospital, Shangrao 334000, China
2. Jiangxi Maternal and Child Health Care Hospital, Nanchang 330000, China
3. Jiangxi Medical College, Shangrao 334000, China
- Publication Type:Research Article
- Keywords:
ovarian low response;
kidney Yin deficiency syndrome;
Guyinjian;
ovarian reserve function;
hemodynamics;
anti mullerian hormone
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(10):87-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of addition and subtraction therapy of Guyinjian on oocyte quality, pregnancy outcome and ovarian reserve function in patients with poor ovarian response (POR) with kidney Yin deficiency syndrome. Method:Ninety patients were randomly divided into control group (45 cases) and observation group (45 cases) by random number table. The patients in both groups got antagonist. Based on such treatment, the patients in observation received additional addition and subtraction therapy of Guyinjian. The using time and amount of gonadotropin (Gn), ovum taking cycle, cycle canceling rate, fertilization rate, available embryo rate, quality embryo rate, ovulation cycle clinical pregnancy rate were recorded. Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), serum estradiol (E2) and endometrial thickness, anti mullerian hormone (AMH), resistance index (RI), pulsation index (PI), end diastolic velocity (EDV) and peak systolic velocity (PSV) were detected. Ratio of PSV/EDV (S/D) was calculated, and scores of kidney yin deficiency syndrome were graded before and after treatment. Result:Total amount of Gn in observation group was less than that in control group (P<0.01), but there was no statistically significant difference in Gn using days and ovum taking cycle between two groups. On the trigger day, level of FSH in observation group was lower than that in control group (P<0.01), while levels of LH and E2 were higher than those in control group (P<0.01). Endometrial thickness was superior to that in control group (P<0.01), and number of acquired eggs was larger than that in control group (P<0.01). Cycle canceling rate in observation group was 13.33%, lower than 17.91%in control group, and the quality embryo rate was 41.86%in observation group, higher than 31.43%in control group; ovulation cycle clinical pregnancy rate was 25%in observation group, higher than 11.94%in control group, but with no statistically significant differences. The fertilization rate was 82.12%in observation group, higher than 72.96%in control group (χ2=5.124, P<0.05). Available embryo rate was 73.71%in observation group, higher than 60.34%in control group (χ2=5.767, P<0.05). After treatment, level of AMH in observation group was higher than that in control group (P<0.01). Score of kidney Yin deficiency syndrome in observation group was lower than that in control group (P<0.01). And levels of RI, PI and S/D were lower than those in control group (P<0.01), while levels of PSV and EDV were lower than those in control group (P<0.01). Conclusion:Addition and subtraction therapy of Guyinjian can increase ovarian blood supply, improve high ovarian reserve function, reduce Gn consumption, increase number of acquired eggs, alleviate symptoms of kidney yin deficiency, and can ameliorate ovarian responsiveness and pregnancy outcome.
