Comparison of in Vitro Dissolution of Active Ingredients in Gastrodiae Rhizoma Powder with Different Particle Size
10.13422/j.cnki.syfjx.20190305
- VernacularTitle: 不同粒径天麻粉中有效成分的体外溶出度比较
- Author:
Fan LIU
1
;
Ting-ting CHEN
1
;
Yan CHEN
1
;
Zi-peng GONG
1
;
Zhi LIU
2
;
Ai-min WANG
1
Author Information
1. Provincial Key Laboratory of Pharmaceutics in Guizhou Province, State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for Development and Application of Ethnic Medicine and Traditional Chinese Medicine, Ministry of Education, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, China
2. The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
- Publication Type:Research Article
- Keywords:
Gastrodiae Rhizoma;
ultrafine powder;
active ingredients;
in vitro dissolution;
gastrodin;
p-hydroxybenzyl alcohol;
parishins
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):124-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare in vitro dissolution behaviors of active ingredients (gastrodin,parishin A,p-hydroxybenzyl alcohol,parishin B and parishin C) in Gastrodiae Rhizoma powder with different particle size.Method: In vitro dissolution of Gastrodiae Rhizoma powder in different dissolution media (water,artificial gastric juice and artificial intestinal juice) were detected by stirring paddle method.Dissolution of these five components in Gastrodiae Rhizoma powder with different particle size was determined by HPLC,mobile phase was acetonitrile-0.1% phosphoric acid solution for gradient elution,column temperature was set at 40℃ and detection wavelength was 220 nm.Result: In water and artificial intestinal juice,the dissolution rates of five active components in three kinds of Gastrodiae Rhizoma ultrafine powders were higher than that of the fine powder and the finest powder;in artificial gastric juice,the dissolution rates of gastrodin and p-hydroxybenzyl alcohol in Gastrodiae Rhizoma ultrafine powders were higher than that of the other powders,and the dissolution rate of parishin A in Gastrodiae Rhizoma ultrafine powders was lower than that of the other powders.Conclusion: An appropriate degree of superfine grinding can promote the dissolution of active ingredients in Gastrodiae Rhizoma,but not as fine as possible.The dissolution medium has an obvious influence on the dissolution behaviors of active components,which provides a reference for screening optical particle size of Gastrodiae Rhizoma powder in clinical application.
