Effect of Modified Xiaokefang on Endothelial Injury, Oxidative Stress and Biochemical Indices of Diabetic Nephropathy Patients of Qi-Yin Deficiency with Blood-stasis Syndrome
10.13422/j.cnki.syfjx.20190830
- VernacularTitle: 消渴方加减对气阴两虚夹瘀型糖尿病肾病的内皮损伤、氧化应激及生化指标的影响
- Author:
Xiao-ze SUN
1
;
Gao-feng TAN
1
;
Ai-hua LIU
1
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
- Publication Type:Research Article
- Keywords:
modified Xiaokefang;
diabetic nephropathy;
endothelial injury;
oxidative stress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):43-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of modified Xiaokefang on endothelial injury,oxidative stress and biochemical indices of diabetic nephropathy (DN) patients of Qi-Yin deficiency with blood-stasis syndrome.Method: Ninety-four patients with DN admitted to our hospital from September 2017 to June 2018 were randomly divided into two groups.The control group (47 cases) was injected with reduced glutathione by intravenous drip.In addition to the therapy of the control group,the observation group (47 cases) was treated with modified Xiaokefang.Before and after treatment,the symptom scores,fasting blood glucose (FBG),2 hpostprandial blood glucose (2 hPG),glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD),malondialdehyde (MDA) and interleukin-1 beta (IL-1β),IL-6,hypersensitive C-reactive protein (hs-CRP),tumor necrosis factor-α(TNF-α),tissue blood fibrin dissolve enzyme activation (t-PA),type 1 original organization fibrin lytic enzyme activators inhibitor (PAI-1),serum creatinine (SCr),blood urea nitrogen (BUN),nitric oxide (NO),endothelin-1(ET-1),24 h total urinary protein levels were observed,and the efficacy of the two groups were observed.Result: After treatment,the total effective rate of the observation group was 89.36%,which was higher than 74.47% of the control group (Z=3.949,P<0.05).The scores of symptoms in the observation group after treatment were lower than those in the control group (P<0.05).After treatment,FBG,2 hPG,SCr,BUN,24 h total urine protein,ET-1,MDA,IL-1β,IL-6,hs-CRP,TNF-α,and PAI-1 levels in the observation group were lower than those in the control group (P<0.05),while NO,SOD,GSH-Px,and t-PA levels were increased (P<0.05).Conclusion: Modified Xiaokefang has a remarkable effect in treatment of diabetic nephropathy patients of Qi-Yin deficiency with blood-stasis syndrome by alleviating clinical symptoms,promoting the recovery of balance of coagulation and fibrinolysis system,inhibiting inflammation and oxidative stress,and protecting endothelial function and renal function.
