Clinical Efficacy of Modified Guizhi Gancao Longgu Muli Tang in Treating Menopausal Insomnia and Its Effect on Sleep Quality and Neurotransmitter
10.13422/j.cnki.syfjx.20190328
- VernacularTitle: 桂枝甘草龙骨牡蛎汤加减治疗阴虚火旺型更年期失眠疗效及对患者睡眠质量、神经递质的影响
- Author:
Yan CAI
1
;
Yu-mei YE
1
;
Tao ZHANG
1
;
Wei YANG
1
;
Gui-yan WANG
1
;
Wei SHI
1
Author Information
1. Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
- Publication Type:Research Article
- Keywords:
menopausal insomnia;
modified Guizhi Gancao Longgu Muli Tang;
sleep quality;
neurotransmitter;
safety;
Yin deficiency fire excess type
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(9):38-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the clinical efficiency of modified Guizhi Gancao Longgu Muli Tang in treating menopausal insomnia.Method: A total of 134 female cases with menopausal insomnia in our hospital from January 2016 to June 2018 were selected as research objectives and randomly divided into observation group (67 cases) and control group (67 cases).Oral zopiclone was provided to control group,and modified Guizhi Gancao Longgu Muli Tang combined with oral zopiclone was provided to observation group.All cases were treated for 4 weeks.The two groups'clinical effects,sleep quality[pittsburgh sleep quality index (PSQI) score],neurotransmitter[glutamate (Glu),γ-aminobutyric acid (GABA),5-hydroxytryptamine (5-HT),dopamine (DA)]levels before and after treatment,as well as adverse reactions were compared.Result: Observation group's overall effective rate was 92.5%(62/67),which was significantly higher than 80.6%(54/67) of control group (P<0.05).Both groups'scores and total scores of the six dimensions including sleep time,sleep efficiency and sleep quality in PSQI (except for the hypnotic drug dimension) after treatment were significantly lower than those before treatment (P<0.05),and observation group's scores and total scores of each dimension (like sleeping time,sleep efficiency,hypnotic drugs) in PSQI after treatment were significantly lower than those in control group (P<0.05).Compared with those before treatment,both groups'serum Glu,DA levels decreases significantly (P<0.05),while serum GABA,5-HT levels increased significantly (P<0.05),and observation group showed more significant improvement (P<0.05).Observation group's adverse reaction rate was lower than that of control group,with no statistically significant difference.Conclusion: Modified Guizhi Gancao Longgu Muli Tang can improve sleep quality,alleviate symptoms of insomnia,and correct neurotransmitter metabolic disorder for patients with menopausal insomnia,with an exact curative effect and a higher tolerance of patients.
