Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media
10.13422/j.cnki.syfjx.20190728
- VernacularTitle: 龙胆泻肝汤对分泌性中耳炎血清炎性因子、相关蛋白及免疫功能的影响
- Author:
Rui WEI
1
;
Yan-hong YUAN
1
;
Lu-lu CHEN
1
;
Hui-min WANG
1
;
Da-jing XIONG
2
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine(TCM), Zhengzhou 450002, China
2. Chengdu University of TCM, Chengdu 611130, China
- Publication Type:Research Article
- Keywords:
Longdan Xiegantang;
secretory otitis media;
gastrointestinal hormones;
inflammatory factors;
immune function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(8):14-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of Longdan Xiegantang on serum inflammatory factors, related proteins and immune function in patients of secretory otitis media (SOM) with liver and gallbladder wetness-heat Syndrome. Method:Totally 76 cases of SOM with liver and gallbladder wetness-heat syndrome admitted to our hospital from July 2017 to May 2018 were randomly divided into two groups, with 38 cases in each group. Control group was treated with triamcinolone acetonide and ambroxol. In addition to the therapy of control group, observation group was also treated with Longdan Xiegantang. Immunoglobulin (Ig) A, IgG, IgM, CD3+, CD4+, CD8+and NK, interleukin-1 beta (IL-1β), IL-5, IL-8, tumor necrosis factor-α (TNF-α), platelet activating factor (PAF), calcitonin (PCT) and water channel protein-1 (AQP-1), AQP-4, fiber link protein (Fn) and soluble interleukin-2 receptor (SIL-2R) levels of two groups were observed before and after treatment. Curative effect and adverse reaction were observed. Result:①Curative effect, after treatment, the total effective rate of observation group was 92.11%, which was higher than 76.32% of control group, with statistically significant differences (Z=2.108, P<0.05). ②Serum inflammatory medium,TNF-α, PAF, PCT, IL-1β and IL-8 in observation group were lower than those in control group after treatment (P<0.05). ③Serum related proteins, in observation group, levels of SIL-2R were lower than those of control group (P<0.05), while the levels of AQP-1, AQP-4 and Fn were higher than those of control group (P<0.05). ④Cellular and humoral immunity, CD8+, IgA, IgG and IgM of observation group were lower than those of control group (P<0.05), while CD3+, CD4+, CD4+/CD8+ and NK were higher than those of control group (P<0.05). ⑤Adverse reactions,the incidence rates of the two groups were 7.89% and 10.53%, respectively, with no statistically significant difference between two groups. Conclusion:Longdan Xiegantang has a remarkable effect in treating patients of secretory otitis media with liver and gallbladder wetness-heat syndrome, and can restore symptoms, inhibit inflammatory response, activate cell and humeral immune system, reduce the secretion of AQP-1, SIL-2R and other proteins, and increase the secretion of AQP-4 and Fn proteins.
