Effect of Modified Bazhentang on Cerebrovascular Reserve and Hemorheology in Patients with Chronic Cerebral Circulation Insufficiency
10.13422/j.cnki.syfjx.20190525
- VernacularTitle: 加减八珍汤对慢性脑供血不足患者脑血管储备功能及血流变学的影响
- Author:
Zhong-bo XU
1
;
Fei-xiang GONG
1
;
Wei-min LIAO
1
;
Xin FENG
2
;
Xin-xin YE
3
Author Information
1. The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang 330006, China
2. Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China
3. School of Nursing, Fujian University of TCM, Fuzhou 350122, China
- Publication Type:Research Article
- Keywords:
modified Bazhentang;
chronic cerebral circulation insufficiency;
cerebrovascular reserve;
hemorheology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(7):43-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of modified Bazhentang on cerebrovascular reserve and hemorheology in patients with chronic cerebral circulation insufficiency. Method: Totally 80 patients treated at Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2018 to June 2018 in line with the inclusion criteria were randomly divided into the observation group (40 cases) and the control group (40 cases) using the random sequence of Stata 13.0. Both groups received basic treatments, such as antihypertensive, hypoglycemic and lipid-lowering. In addition to the therapy of the control group, the control group was also given nimodipine tablet treatment, and the observation group was given modified Bazhentang treatment, with a total course of 30 days. Before and after treatment, transcranial doppler ultrasonography (TCD) was used to detect the cerebrovascular reserve function of the two groups, so as to evaluate the clinical efficacy, and detect the hemorheology, blood routine, hepatic and renal function. Result: The effective rate of the observation group was 92.5%, and that of the control group was 80%. The clinical efficacy of the observation group was better than that of the control group (P<0.05). Compared with before treatment, cerebrovascular reserve (CVR), breath-holding index (BMI) and mean blood flow velocity (Vm) were significantly increased in the observation group after treatment (P<0.05). Compared with before treatment, hematocrit, whole blood apparent viscosity high cut, low cut, plasma viscosity were all decreased in the observation group after treatment (P<0.05). After treatment, CVR, BMI, and Vm of the observation group were higher than those of the control group (P<0.05), and hematocrit, whole blood apparent viscosity high cut, low cut, plasma viscosity of the observation group were lower than those of the control group (P<0.05). Safety indexes of the two groups were in the normal range after treatment, with no statistical difference compared with before treatment. Conclusion: Modified Bazhentang can effectively treat chronic cerebral circulation insufficiency. By improving the function of cerebrovascular reserve and cerebral blood flow, it can alleviate clinical symptoms without safety problems, so as to provide a theoretical basis for the treatment of chronic cerebral circulation insufficiency with traditional Chinese medicine.
