Protective Effect of Traditional Chinese Medicine on Ischemic Myocardium by Mitochondrial Autophagy
10.13422/j.cnki.syfjx.20190605
- VernacularTitle: 中药通过线粒体自噬保护缺血心肌的研究进展
- Author:
Yu-wei ZHAO
1
;
Jian-hua FU
1
;
Lei LI
1
;
Ling-mei LI
1
;
Gao-jie XIN
1
;
Qiu-sheng ZHENG
2
;
Jian-xun LIU
1
Author Information
1. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
2. Binzhou Medical University, Yantai 264033, China
- Publication Type:Research Article
- Keywords:
ischemic heart disease;
mitochondria;
autophagy;
traditional Chinese medicine(TCM)
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(6):210-217
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic heart disease is one of the most deadly diseases in the world, and new therapies and preventive measures are urgently needed. In general, cardiomyocytes rely on adenosine triphosphate(ATP) produced by mitochondrial oxidative phosphorylation to maintain their systolic and ion pump functions. Autophagy is a procedural degradation mechanism widely present in eukaryotic cells. It is a self-defense mechanism and self-repair process of the body tissues. It is also a way of apoptosis and a basic phenomenon to maintain the energy balance of human cells. Mitochondrial autophagy is a type of selective autophagy in cells. In fact, damaged mitochondria selectively remove damaged proteins and organelles with autophagy to maintain intracellular homeostasis. Mitochondrial autophagy is important for maintaining the homeostasis of cardiomyocytes. With the deepening of modern biological research, more and more traditional Chinese medicines(TCM) or their extracts have been proven to alleviate myocardial cell damage after ischemia/reperfusion through autophagy or regulation of mitochondrial function. This further inspires TCM workers to find effective treatment measures by targeting mitochondria. Under the above background, this paper reviews the effects of mitochondrial autophagy on ischemic heart disease and the intervention studies of TCM in this field.
