Clinical Efficacy of Xiaoai Jiedu Formula Combined with FEC Chemotherapy on Breast Cancer Patients
10.13422/j.cnki.syfjx.20190426
- VernacularTitle: 消癌解毒方联合FEC化疗对乳腺癌患者临床疗效的影响
- Author:
Jing-yun PAN
1
;
Hai-bo CHENG
1
Author Information
1. First Clinical Medical College, Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Tumors Prevention and Treatment with Traditional Chinese Medicine, Nanjing 210000, China
- Publication Type:Research Article
- Keywords:
breast cancer;
carcinomas;
Xiaoai Jiedu formula;
Chaihu Shugan San;
Shengmaiyin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(6):95-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe effect of Xiaoai Jiedu formula combined with fluorouracil (5-FU)+epirubicin (EPI)+cyclophosphamide (CTX) (FEC) chemotherapy regimen on immune function, tumor index, traditional Chinese medicine (TCM) symptom scale score and adverse reactions of patients with breast cancer. Method:A total of 60 patients with breast cancer were randomly divided into study group and control group. FEC (CTX 0.6 g·m-2,d1,EPI 100 mg·m-2,d1,5-FU 0.5 g·m-2,d1) regimen was used in study group, and Xiaoai Jiedu formula recipe was used for two consecutive cycles. FEC regimen was used in control group only. After 2 cycles, immunological changes, tumor index, TCM symptom score and adverse reactions were analyzed and compared between two groups. Result:There was not significant difference in immune indexes between two groups before treatment, but statistically significant differences after treatment (P<0.05). There was no statistically significant difference in levels of carcinoembryonic antigen(CEA) and carbohydrate antigen153(CA153) between two groups before treatment; CEA and CA153 levels significantly decreased in both groups, particularly in study group (P<0.05). There was no statistically significant difference in scores of fatigue, hot flashes and night sweats, irritability, dry mouth, appetite and sleep between two groups before treatment. The scores in study group were significantly lower than those in control group after treatment (P<0.05). The incidence of menstrual disorder, nausea, vomiting and constipation in study group was lower than that in control group (P<0.05). Conclusion:Xiaoai Jiedu formula combined with FEC chemotherapy can improve clinical efficacy and alleviate clinical symptoms of patients.
