Research on Quality Control Model of Ancient Famous Classical Formulas Based on Supramolecular Theory
10.13422/j.cnki.syfjx.20191652
- VernacularTitle: 基于超分子理论探索古代经典名方的质量控制模式
- Author:
Peng HE
1
;
Hai-ying LI
1
;
Qi-meng FAN
1
;
Xue PAN
1
;
Yu-ting HE
1
;
Yan YANG
1
;
Mei-feng XIAO
1
;
Fu-yuan HE
1
Author Information
1. College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China
- Publication Type:Research Article
- Keywords:
supramolecular theory;
ancient famous classical formulas;
imprinting template;
quality control;
transitivity;
stability;
homogeneity
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(16):161-166
- CountryChina
- Language:Chinese
-
Abstract:
The ancient famous classical formulas were developed based on the characteristics of excellent curative effect, small toxic and side effects, and wide clinical application. Its development will promote the development of traditional Chinese medicine (TCM) with huge social and economic benefits. TCM and TCM compounds are multi-component systems, which are multi-component, multi-target and multi-pathway effect on human body, their curative effect is the result of synergistic effect of multi-component. Because of its characteristics, its mechanism of action is still unclear and quality is difficult to control. Therefore, on the basis of biological properties of the multi-components of TCM, it is the key issue to study the preparation process of the medicinal materials-decoction pieces-preparations and the transferability, stability and homogeneity of the quality attributes. Moreover, the supramolecular theory can explain the basic theory of TCM from the macroscopic and microscopic aspects, the study of ancient famous classical formulas can use the supramolecular theory. Both TCM and human body are giant complex supramolecules, and their components are clustered objects reflecting the characteristics of the original imprinting template with genetic polymorphism. The quality attributes, processing, formulation preparation and quality attribute evaluation of TCM are all affected by supramolecular chemistry, which is finally reflected in the preparation of imprinting template and the transfer law of quality properties. Therefore, the application of supramolecular imprinting template theory to study the biogenetic polymorphism of TCM, processing, formulation preparation and quality attribute evaluation of medicinal materials can improve the availability rate of successful research and development of ancient famous classical formulas.
