Molecular Mechanism of Sanjie Zhentong Capsule in Treatment of Endometriosis, Adenomyosis, Secondary Dysmenorrhea
10.13422/j.cnki.syfjx.20191604
- VernacularTitle: 散结镇痛胶囊入血成分治疗子宫内膜异位症、子宫腺肌症及继发性痛经的作用机制探讨
- Author:
Zhen-zhen SU
1
;
Zhi-peng KE
1
;
Xin-zhuang ZHANG
1
;
Liang CAO
1
;
Zhen-zhong WANG
1
;
Wei XIAO
1
Author Information
1. Jiangsu Kanion Pharmaceutical Co. Ltd., State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222000, China
- Publication Type:Research Article
- Keywords:
Sanjie Zhentong capsule;
network pharmacology;
endometriosis;
adenomyosis;
secondary dysmenorrheal
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(17):165-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the pharmacological basis and molecular mechanism of Sanjie Zhentong capsule in the treatment of endometriosis, adenomyosis, secondary dysmenorrhea. Method: The 6 compounds of Sanjie Zhentong capsule showed stronger interactions with 87 proteins relating to endometriosis, adenomyosis, and secondary dysmenorrhea in molecular docking. Then the drug-target network was selected, and the network features were analyzed. Result: The molecular docking and network characteristics revealed 5 main active molecules and 23 potential targets of Sanjie Zhentong capsule. Conclusion: The main active ingredients of Sanjie Zhentong capsule have a trong inhibition effect on endometrial angiogenesis and blood circulation, uterine smooth muscle contraction, immune inflammatory reaction and estrogen secretion by acting on the targets of inflammation, cell invasion, metastasis, coagulation system, smooth muscle contraction and neurohormone regulation, so as to treat endometriosis, adenomyosis and secondary dysmenorrhea.
