Effect of Modified Chaihu Guizhi Ganjiang Tang in Treating Chronic Cholecystitis of Gallbladder Heat
10.13422/j.cnki.syfjx.20191127
- VernacularTitle: 柴胡桂枝干姜汤加味治疗胆热脾寒型慢性胆囊炎疗效及对炎症因子、胆囊功能及胃肠功能的影响
- Author:
Rui GU
1
;
Yao-yao LU
1
;
Hong-shan DAI
1
;
De-xuan CHEN
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
- Publication Type:Research Article
- Keywords:
modified Chaihu Guizhi Ganjiang Tang;
chronic cholecystitis;
gallbladder heat and spleen cold syndrome;
inflammatory response;
intestinal function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(17):64-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the clinical effect of modified Chaihu Guizhi Ganjiang Tang in the treatment of chronic cholecystitis with gallbladder heat and spleen cold syndrome. Method: Totally 129 cases with chronic cholecystitis treated in our hospital from March 2017 to July 2018 were selected as study objectives and randomly divided into observation group (65 cases)and control group (64 cases). After the shedding and exclusion cases were subtracted, 61 patients in observation group and 61 patients in control group actually completed this study. The routine treatment was provided to both groups, and modified Chaihu Guizhi Ganjiang Tang was additionally given to observation group. All of the cases received treatments for 3 weeks. The two groups' clinical effect, traditional Chinese medicine(TCM)syndrome scores, inflammatory factors[interleukin (IL)-6, tumor necrosis factor (TNF)-α] levels in serum, gallbladder function, gastrointestinal function indicators[motilin (MTL), vasoactive intestinal peptide (VIP)] before and after treatments, as well as toxic side reaction were compared. Result: Totally 7 cases were lost during the study period. The overall effective rate of the observation group was 95.08%(58/61), which was significantly higher than 80.33%(49/61)of the control group (P<0.05). The scores of two groups (the right upper quadrant pain and discomfort, belch, diarrhea, et al)and serum IL-6, TNF-α concentrations after treatment were significantly lower than those before treatment (P<0.05), gallbladder contractile function and serum MTL content were improved significantly (P<0.05), which was more significant in observation group (P<0.05). There was no significant side effect in both groups. Conclusion: Modified Chaihu Guizhi Ganjiang Tang treats patients with chronic cholecystitis with bile heat and spleen cold syndrome by effectively relieving inflammatory response and accelerating the recovery of gastrointestinal function and gallbladder systolic function, with an exact curative effect and high patient tolerance.
