Overview on Animal Models of Throat Impediment
10.13422/j.cnki.syfjx.20191036
- VernacularTitle: 喉痹动物模型的研究现状及评价分析
- Author:
Jia-bao WU
1
;
Dong-fang HUANG
1
;
Ye WANG
1
;
Jie MENG
1
;
Jin-fu LU
2
;
Xia ZHAO
1
Author Information
1. Affiliated Hospital of Nanjing University of Chinese Medicine, Key Laboratory of Pediatric Respiratory Disease of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China
- Publication Type:Research Article
- Keywords:
throat impediment;
pharyngitis;
animal model
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(18):189-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize and evaluate the existing animal models of pharyngitis, in order to provide a theoretical basis for its treatment and research of traditional Chinese medicine (TCM) for throat impediment. Method: Nearly 5 years of literatures were retrieved form databases of Chinese national knowledge infrastructure (CNKI), SinoMed and Pubmed, with throat impediment, pharyngitis, and animal model as medicine subject headings terms. Result: At present, rats, rabbits, guinea pigs and macaques are available as model animals. The main methods for reproduction of pharyngitis animal model were direct ammonia molding, ammonia and turpentine combined molding and bacterial injection molding. The rarely used methods, such as pyridine induction method, capsaicin induction method and sand dust induction method, have their own characteristics. The pharyngitis animal models with the combination of TCM syndrome include YIN-deficiency type and stagnation of liver-Qi with deficiency of spleen type. These models evaluation indexes were diverse, including apparent behavior, histopathology, biochemical indicator and hemorheology. The problems of these modeling methods included the differences in etiology and mechanism between the methods of modeling and the formation of clinical patients, the lack of molecular level of pathological mechanism elaboration, the non-uniform standard for concentration, frequency and cycle of drug administration during modeling, the subjectivity in judging partial evaluation indexes and the deficiency of the pharyngitis animal model with the combination of TCM syndrome. Conclusion: Firstly, the existing models needed to be further improved by such means as the exploration of the correlation or consistency between the molecular pathology mechanism and the clinical pathogenesis, and the concentration and frequency of uniform model administration and uniform standard for evaluation indexes. Secondly, the pharyngitis animal model with the combination of TCM syndrome and modern medicine disease was urgently needed to be explored, in order to facilitate the development of basic research in TCM.
