Short-term and Long-term Efficacy of Modified Qingweisan in Treatment of Acute Pulpitis of Children with Syndrome of Hyperactivity of Gastric Fire
10.13422/j.cnki.syfjx.20191536
- VernacularTitle: 清胃散加减治疗儿童急性牙髓炎胃火炽盛证的近期和远期疗效观察
- Author:
He-sheng WANG
1
;
Xing-an ZHANG
1
;
Da-qing WANG
2
;
Ling ZENG
1
Author Information
1. Nanchong Central Hospital, Nanchong 637000, China
2. The Affiliated Hospital of North Sichuan Medical College, Nanchong 637600, China
- Publication Type:Research Article
- Keywords:
acute pulpitis;
syndrome of hyperactivity of gastric fire;
Qingweisan;
disposable root canal therapy;
inflammatory factors;
calcitonin gene-related peptide;
Substance P
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(18):95-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the efficacy of modified Qingweisan on acute pulpitis (AP) of children with syndrome of hyperactivity of gastric fire and its effect on inflammatory factors. Method: One hundred and six patients were randomly divided into control group (52 cases) and observation group (54 cases) by random number table. Patients in control group got one-off root canal therapy, and azithromycin for suspension after the therapy for a continued 3 days, 10 mg·kg-1, 3 times/days. In addition to the therapy of control group, patients in observation group were also given modified Qingweisan for 7 days, 1 dose/day. Before treatment and at the 1st, 3rd, 5th and 7th days after treatment, visual analogue scale (VAS), faces rating scale-revised (FPS-R), verbal rating scale and traditional Chinese medicine (TCM) syndrome were scored before and after treatment. And pain relief time and time for masticatory function returned to normal were recorded. And levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, calcitonin gene-related peptide (CGRP) and substance P were detected. And a 6-month follow-up was carried out to record the success or failure. Result: At the 3rd, 5th and 7th days after treatment, score of VAS in observation group was lower than that in control group(P<0.01). At the 3rd and 7th days after treatment, score of FPS-R was lower than that in control group (P<0.01). At the 7th days after treatment, degree of pain in observation group was lighter than that in control group (P<0.05). Pain relief time and time for masticatory function returned to normal in observation group were shorter than those in control group (P<0.01). Score of TCM syndrome was lower than that in in control group(P<0.01). And levels of CRP, TNF-α, IL-1β, IL-6, CGRP and SP were all lower than those in control group(P<0.01). According to 6-month follow-up, success rate in observation group was 81.48%, which was lower than 78.85%in control group, with no statistical significant difference between two groups. Conclusion: Modified Qingweisan can inhibit expressions of inflammatory factors and pain transmitters, ameliorate the pain and shorten course of disease among children after disposable root canal therapy, with a satisfactory short-term effect.
