Clinical Observation of Addition and Subtraction Therapy of Taohong Siwutang Combined with Chaihu Shugansan to Unstable Angina Pectoris with Type A Behavior Pattern
10.13422/j.cnki.syfjx.20191834
- VernacularTitle: 桃红四物汤合柴胡疏肝散加减治疗不稳定型心绞痛A型行为的临床观察
- Author:
Li-mei YUAN
1
;
Li-hua FAN
2
;
Zhi-guo ZHANG
2
;
Qing-hai LI
2
Author Information
1. Henan University of Chinese Medicine, Zhengzhou 450008, China
2. Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450008, China
- Publication Type:Research Article
- Keywords:
unstable angina pectoris;
type A behavior pattern;
Qi stagnation and blood stasis syndrome;
Taohong Siwutang;
Chaihu Shugansan;
proinflammatory factors;
serotonin
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(18):89-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the clinical efficacy of addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan to unstable angina pectoris with type A behavior pattern (Qi stagnation and blood stasis syndrome), and investigate its effects on proinflammatory factors and serotonin (5-HT). Method: One hundred twenty-four patients were randomly divided into control group (60 cases) and observation group(64 cases) by random number table. Patients in control group got Aspirin enteric-coated tablets, 100 mg/time, 1 time/day. Tigrillo tablets, 90 mg/time, 2 times/days. Metoprolol tartrate tablets, 50 mg/time, 2 times/days. Simvastatin tablets, 10 mg/time, 1 time/day. Nitroglycerin tablets, 0.5 mg/time. Based on the treatment in control group, patients in observation group also received addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan, 1 dose/day. The treatment course was 8 weeks in both groups. Number of attacks, duration, degree of pain and usage of nitroglycerin were recorded for every week. Before and after treatment, electrocardiogram was also recorded. And levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), hypersensitive C-reactive protein and 5-HT were detected. In addition, scores of Seattle Angina Scale (SAQ) and Qi stagnation and blood stasis syndrome were graded. Result: In the rank sum test, the curative effect in electrocardiogram of observation group was better than that of control group (Z=1.965, P<0.05). Number of attacks, duration, degree of pain and usage of nitroglycerin were all less than those in control group (P<0.01). Scores of various dimensions in SAQ and the total scores of SAQ were all higher than those in control group (P<0.01). Scores of various symptoms for Qi stagnation and blood stasis syndrome and the total scores were lower than those in control group (P<0.01). Levels of LDL-C, IL-6, hs-CRP, TNF-α and 5-HT in observation group were lower than those in control group (P<0.01), while level of HDL-C was higher than that in control group (P<0.01). Conclusion: On the basis of conventional western medicine, addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan can further control angina attack, relieve clinical symptoms, improve quality of life, regulate lipid metabolism, and can inhibit expression of proinflammatory factors and 5-HT, so it can play a role in stabilizing the disease.
