Anti-leukemia Mechanism and Problems of Volatile Oil from Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20191229
- VernacularTitle: 中药挥发油抗白血病机制及问题探讨
- Author:
Jin-song DENG
1
;
Hai-yan ZHANG
1
;
Qi-yue YANG
2
;
Sheng-xing WU
1
;
Zhen-chao WANG
1
;
Yan LI
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM) Under Ministry of Education, National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of TCM, Nanchang 330004, China
2. Chengdu University of TCM, Chengdu 610075, China
- Publication Type:Research Article
- Keywords:
volatile oil of traditional Chinese medicine;
leukemia;
cell proliferation;
apoptosis;
problem discussion
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(19):226-234
- CountryChina
- Language:Chinese
-
Abstract:
Leukemia is a hematopoietic hyperplastic disease with an increasing incidence year by year, involving bone marrow and lymphatic system. The disease is complex and a highly heterogeneous disease, including a variety of subtypes, with difficulties in treatment and a poor prognosis. Currently, retinoic acid and its derivatives, arsenic are commonly used in clinical treatment as leukemia cell differentiation inducers. However, their clinical range of treatment is mostly restricted to granulocytic leukemia, with a high price and certain toxic and side effects. With the development of molecular genetics, molecular biology, second-generation sequencing and other technologies, the etiology and pathology of leukemia has been significantly studied, but the specific pathogenesis of leukemia has still been unclear. With the further promotion of molecular targeted drugs, chimeric antigen receptor T-cell immunotherapy (CAR-T) and hematopoietic stem cell transplantation, although the treatment of leukemia has entered a new field, compared with traditional chemotherapy, these therapies have high costs, and the long-term efficacy is yet to be further confirmed. After years of basic research and clinical research, traditional Chinese medicine(TCM) volatile oil in the treatment of leukemia has made remarkable achievements. Essential oil can alleviate the toxic and side effect of chemotherapy drugs, effectively prolong or prevent the relapse of leukemia, inhibit the proliferation of leukemia cells, and promote the apoptosis of leukemia cells. In this paper, the authors reviewed relevant domestic and foreign literatures by literature tracking method, summarized the anti-leukemia mechanism of essential oil of TCM, analyzed the characteristics and existing problems of essential oil of TCM, and proposed the improvement direction, in order to provide reference for accelerating the research and development and innovation of essential oil in the treatment of leukemia.
