Advances in Research on Mechanism of Salvianolic Acid B Against Oxidative Stress
10.13422/j.cnki.syfjx.20192005
- VernacularTitle: 丹酚酸B抗氧化应激损伤机制的研究进展
- Author:
Li-ping AN
1
;
Kun YU
1
;
Hai-bo GENG
2
;
Wei WANG
1
Author Information
1. Basic Medical College, Hebei University of Chinese Medicine, Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Shijiazhuang 050200, China
2. Department of Food and Pharmaceutical Engineering, Shijiazhuang Vocational and Technical College, Shijiazhuang 050081, China
- Publication Type:Research Article
- Keywords:
salvianolic acid B;
oxidative stress;
signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(22):227-234
- CountryChina
- Language:Chinese
-
Abstract:
Salvia miltiorrhiza Bge was first published in Shennong Bencaojing. Salviae Miltiorrhizae Radix et Rhizoma has the effect of promoting blood circulation, cooling blood and eliminating phlegm. Modern pharmacological studies have found that Salviae Miltiorrhizae Radix et Rhizoma has strong heart, improve microcirculation and antithrombotic effects. The decoction of Salviae Miltiorrhizae Radix et Rhizoma is commonly used in clinical practice. The dissolved component of Salviae Miltiorrhizae Radix et Rhizoma is mainly salvianolic acid. Among them, salvianolic acid B is one of the water-soluble components of Salviae Miltiorrhizae Radix et Rhizoma. It has strong physiology. Activity, salvianolic acid B is the strongest antioxidant activity of salvianolic acids. Salvianolic acid B regulates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, decoupled endothelial nitric oxide synthase (eNOS) in vivo, and regulates Janus protein tyrosine kinase 2/signal transducer and transcriptional activation 3/vascular endothelial growth factor (JAK2/STAT3/VEGF) and tumor suppressor(p53), B cell lymphoma-2(Bcl-2), Bcl-2-related X protein (Bax), Caspase-3 anti-apoptotic pathway, inhibition of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK), c-Jun N-terminal kinase/mitogen-activated protein kinase (JNK/MAPK), mitogen-activated protein kinase p38 (p38MAPK) and estrogen receptor alpha/phosphatidylinositol 3-kinase/serine-threonine protein kinase/nuclear transcription factor kappa B (ERα/PI3K/Akt/NF-κB) anti-inflammatory pathway, silencing information regulator 2 related enzyme 1/nuclear factor E2 related factor 2/Kelch-like ECH combined protein 1-antioxidant response element (SIRT1/Nrf2/Keap1-ARE) and NAD-dependent deacetylase sirtuin Forkhead transcription factor 1/superoxide dismutase on-3/β cells (NAD-dependent deace tylase sirtuin-3, SIRT3/FOXO1/SOD2) antioxidant pathway and autophagy pathway inhibit oxidative stress and protect tissues and organs from oxidative damage. Based on the study of the pathway of salvianolic acid B against oxidative stress injury, this paper reviews the related research published in domestic and foreign journals in the past five years, and provides new ideas for expanding the clinical application range of salvianolic acid B.
