Effect of Wenfei Zhiliudan in Treating Lung Qi Deficiency Cold Type Allergic Rhinitis and Its Mechanism
10.13422/j.cnki.syfjx.20191424
- VernacularTitle: 温肺止流丹治疗肺气虚寒型变应性鼻炎及机制
- Author:
Wen-ming CHEN
1
;
Jing-bo LI
1
;
Hui-min WANG
1
;
Jun-jie WANG
1
;
Feng CHAI
1
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
- Publication Type:Research Article
- Keywords:
allergic rhinitis;
Wenfei Zhiliudan;
lung Qi deficiency cold type
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(22):55-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the efficacy and safety of Wenfei Zhiliudan in treatment of lung Qi deficiency cold type allergic rhinitis. Method: A total of 120 cases were randomly divided into control group and observation group, with 60 cases in each group. The control group was given desloratadine + momethasone furoate, while observation group was given Wenfei Zhiliudan. A course of treatment was 2 weeks. The rhino conjunctivitis quality of life questionnaire (RQLQ), total nasal symptom score (TNSS) and traditional Chinese medicine (TCM) syndrome differentiation scale for lung Qi deficiency cold (TCM scale) in two groups before and after treatment were observed. The serum inflammatory factor[tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-33 (IL-33)]and immune indexes[immunoglobulin E (IgE), eosinophils (EOS), eotaxin (EOT)]were determined. The total effective rate and the incidence of adverse reactions were compared between two groups. Result: Five cases felt off during the study period. The total effective rate in observation group was 91.5%(54/59), which was higher than 82.5%(47/57) in control group (P<0.05). The RQLQ, TNSS and TCM scale scores in observation group were significantly lower than those in control group (P<0.05). The serum levels of inflammatory factors (TNF-α, IFN-γ, IL-33) in observation group were significantly lower than those in control group (P<0.05). The serum levels of immune indexes (IgE, EOS) in observation group were significantly lower than those in control group (P<0.05), while EOT in observation group were significantly higher than that in control group (P<0.05). The incidence of adverse reactions was 1.7%(1/59) in observation group, which was lower than 19.3%(11/57) in control group (P<0.05). Conclusion: Wenfei Zhiliudan can significantly alleviate the clinical symptoms, serum inflammatory factors and immune indicators of lung Qi deficiency cold type allergic rhinitis, with a lower incidence of adverse reactions.
