Research Progress of Gardeniae Fructus in Treatment of Cerebral Ischemia
10.13422/j.cnki.syfjx.20200349
- VernacularTitle: 栀子治疗脑缺血的研究进展
- Author:
Yun WANG
1
;
Dong-ying LI
2
;
Fan-kai LIN
3
;
De-peng LIU
1
;
Xue ZHANG
1
;
Guo-you WANG
1
;
Yin-lian MA
1
;
Cun ZHANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. Beijing Zhongyan Tongrentang Pharmaceutical Research and Development Co. Ltd., Beijing 100079, China
3. School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China
- Publication Type:Research Article
- Keywords:
Gardeniae Fructus;
cerebral ischemia;
geniposide;
crocin;
croceic acid;
mechanism;
anti-inflammatory
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(24):226-234
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is one of the diseases that seriously threaten human health. It is characterized by the high morbidity, disability rate and mortality, and has been lacking effective treatment. Its occurrence is related to metabolic disorder, calcium overload, free radical injury, inflammatory reaction, etc. Gardeniae Fructus not only has antipyretic, analgesic, hepatoprotective and cholagogic effects, but also has protective effects against ischemic brain injury. At present, there are more studies about the main components of Gardeniae Fructus against ischemic brain injury, but the mechanism is unclear. In this paper, the mechanism of the main active ingredients from Gardeniae Fructus in the treatment of cerebral ischemia injury in recent years was reviewed, and the effective component monomer and the whole were analyzed, so as to provide a basis for the prevention and treatment of ischemic brain injury of Gardeniae Fructus decoction pieces, and provide a reference for further research and application of this decoction pieces.
