Research and Development Strategy of Classical Formula Compound Preparation
10.13422/j.cnki.syfjx.20192445
- VernacularTitle: 经典名方复方制剂研发策略
- Author:
Yan LIU
1
;
Jun ZHANG
1
;
Shi-lin CHEN
1
;
Jing-tang CHEN
1
;
Dong-xue LI
2
;
An LIU
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China
2. China National Center for Biotechnology Development, Beijing 100039, China
- Publication Type:Research Article
- Keywords:
classical famous formulae;
compound preparation;
research and development strategies;
evaluation of draggability;
industrialization;
clinical orientation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(24):166-172
- CountryChina
- Language:Chinese
-
Abstract:
Although the country has promulgated a list of 100 classical famous formula,there are still many confusions and choices in the development of compound preparations from classical prescriptions. In this paper,the development strategy of classical formula compound preparation was elaborated from three aspects:the evaluation of draggability,the consideration of industrialization and the clinical orientation. The draggability evaluation includes pharmacy and preclinical safety. It should focus on the factors such as substance benchmark,dosage,toxic herbal medicines,clinical use and so on. Industrialization considerations need to focus on how to use modern industrialization methods to prepare modern compound preparations with the same quality as material benchmarks. The use of extracts may be an effective way to solve the problems of low utilization rate of decoction pieces and inadequate industrial advantages. Clinical orientation should be clear about the main effect,take into account the secondary effect, pay attention to the negative effect, and consider the level of clinical value. A series of corresponding development strategies and ideas are proposed in order to provide references for enterprises and researchers who select and layout classical famous formula, to promote the development of classical prescription compound preparation.
