Comprehensive Optimization of Rehabilitation Measures of Traditional Chinese Medicine to Elderly Patients with COPD at Stable Period
10.13422/j.cnki.syfjx.20192133
- VernacularTitle: 老年患者稳定期COPD的中医辨证及康复措施治疗的临床观察
- Author:
Yi CHENG
1
;
Liang FAN
1
;
Yue-hua LIN
1
;
Rong CHEN
1
;
Hai-ling ZHAO
1
;
Hui-fen HUANG
1
Author Information
1. Haikou Traditional Chinese Medicine Hospital, Haikou 570216, China
- Publication Type:Research Article
- Keywords:
chronic obstructive pulmonary disease;
stable phase;
Yupingfeng granule;
Bailing capsule;
Slow-branching Guben granule;
Lily Gujin pills;
immune function;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(24):48-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the clinical efficacy of comprehensive optimization of rehabilitation measures of traditional Chinese medicine(TCM) on elderly patients with COPD at stable period, in order to study its effect on immune function and inflammatory factors. Method:One hundred and forty-four patients were randomly divided into control group and observation group by random number table. Patients in control group got ipratropium bromide, 40-80 μg/time, 2-4 times/days, salmeterol roticasone powder, 1 suction/time, 2 times/days, as well as comprehensive western medical treatment measures of healthcare education, oxygen therapy and respiratory muscle exercise. In addition to the basic therapy of ipratropium bromide and salmeterol roticasone powder, patients in observation group was added with syndrome differentiation therapy of TCM, foot bath with TCM and respiratory function exercise with TCM. The course of treatment was 6 months, and 6-month follow-up were recorded. Comprehensive assessment of COPD was recorded. Before and after treatment, respiratory questionnaire (mMRC), self-assessment test for patients with chronic obstructive pulmonary disease (CAT), forced expiratory volume in the first second (FEV1), FEV1%, St George's respiratory questionnaire (SGRQ), 6-minute walking distance (6 MWD) were scored. And levels of CD3+, CD4+, CD8+, CD4+/CD8+, interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) and hypersensitive C-reactive protein (hs-CRP) were detected. Result:Comprehensive assessment of COPD in the two groups were better than those before treatment (P<0.05), and that in observation group was better than that in control group (Z=2.066, P<0.05). And scores of mMRC, CAT, SGRQ, hs-CRP, IL-6, IL-8 and TNF-α were lower than those in control group (P<0.01), and level of CD8+ was lower than that in control group (P<0.05). And levels FEV1 and FEV1% were higher than those in control group (P<0.05), and levels of CD3+, CD4+, CD4+/CD8+ and 6-minute walking distance were more than those in control group (P<0.01). Conclusion:Comprehensive optimization of rehabilitation measures in TCM can inhibit inflammatory factors, improve immune function, alleviate clinical symptoms, improve lung function, improve exercise endurance and quality of life of patients, and promote the lung rehabilitation.
