Effects of 5-hydroxytryptamine and receptors in tumorigenesis
10.3760/cma.j.issn.1673-422X.2019.11.008
- VernacularTitle: 5-羟色胺及其受体在肿瘤发生发展中的作用
- Author:
Yang LI
1
;
Zhongxin LI
2
;
Yitao JIA
3
Author Information
1. Graduate School, North China University of Technology, Tangshan 063210, China; Third Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, China
2. Second Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
3. Third Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, China
- Publication Type:Review
- Keywords:
Serotonin;
Receptors;
Immunity;
Neoplasms
- From:
Journal of International Oncology
2019;46(11):682-685
- CountryChina
- Language:Chinese
-
Abstract:
The role of 5-hydroxytryptamine (5-HT) has attracted more and more attention in the development of tumor. In addition to the synthesis of 5-HT by enterochromaffin cells, some tumor cells and immune cells can also secrete 5-HT, and there are different 5-HT receptors on the surface of these cells. 5-HT plays multiple biological effects through activating different receptors. 5-HT promotes the proliferation and invasion of tumor and induces the angiogenesis of tumor tissues through activating its corresponding receptors, such as 5-HT1D, and so on. Furthermore, various 5-HT receptors are expressed on the surface of immune cells. On the one hand, physiological doses of 5-HT promote the proliferation and secretion of immune cells. On the other hand, pathologic 5-HT has an effect on inducing the differentiation of immune cells in the direction of immunosuppression, thus participating in the occurrence and development of tumor.
