Advances in intervention measures for hepatic ischemia-reperfusion injury
10.3760/cma.j.issn.1007-8118.2019.11.020
- VernacularTitle: 肝脏缺血再灌注损伤干预措施的研究进展
- Author:
Zhongshan LU
1
;
Wei WANG
1
;
Zibiao ZHONG
1
;
Qifa YE
2
;
Guizhu PENG
1
Author Information
1. Zhongnan Hospital of Wuhan University; Institute of Hepatobiliary Diseases of Wuhan University; Transplant Center of Wuhan University; Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China
2. Zhongnan Hospital of Wuhan University; Institute of Hepatobiliary Diseases of Wuhan University; Transplant Center of Wuhan University; Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China; The Third Xiangya Hospital of Central South University; Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha 410013, China
- Publication Type:Review
- Keywords:
Liver;
Reperfusion injury;
Intervention
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(11):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury is an inevitable clinical phenomenon during the liver transplantation. The mechanism of hepatic ischemia-reperfusion injury is complex, with reactive oxygen species, inflammatory factors, calcium overload, neutrophils and Kupffer cells involved. If injury continues to getting worsen, liver cells will undergo necrosis, apoptosis, and autophagy. Interventions for hepatic ischemia-reperfusion injury mainly include ischemic preconditioning, drug pretreatment, chemical pretreatment, mild hypothermia pretreatment, and machine perfusion and gene-targeted therapy in recent years. With the indepth research of injury mechanism, new intervention methods continue to emerge, which will bring new ideas for clinical prevention and treatment of liver ischemia-reperfusion injury.
