Advances of Nogo-A protein in the mechanism of epilepsy
10.3760/cma.j.issn.1006-7876.2019.11.019
- VernacularTitle: Nogo-A蛋白参与癫痫发生机制的研究进展
- Author:
Jinwei ZHANG
1
;
Tao CHEN
1
;
Sixun YU
2
;
Haifeng SHU
2
;
Yongqin KUANG
1
Author Information
1. Department of Clinical Medicine, Chengdu Medical College, Chengdu 610500, China; Department of Neurosurgery, the General Hospital of Western Theater Command of People′s Liberation Army, Chengdu 610083, China
2. Department of Clinical Medicine, Chengdu Medical College, Chengdu 610500, China
- Publication Type:Review
- Keywords:
Nogo-A;
Epilepsy;
Dendrites;
Glia;
Nerve migration
- From:
Chinese Journal of Neurology
2019;52(11):967-973
- CountryChina
- Language:Chinese
-
Abstract:
The myelin-associated protein Nogo-A was considered to be the axon growth inhibitory factor, which participates in a variety of pathophysiological regulation of nervous system. In recent years, a growing number of studies have shown that Nogo-A protein is closely related to epilepsy by regulating dendritic plasticity, mediating abnormal nerve migration and regulating glial cell activation, etc. This article will review the research progress of Nogo-A in epilepsy in recent years.
