A CXCL12/CXCR4 axis in regulation of tumor behaviors by ionizing radiation
10.3760/cma.j.issn.0254-5098.2019.12.015
- VernacularTitle: 电离辐射通过CXCL12/CXCR4信号轴调控肿瘤生物学行为的研究进展
- Author:
Qing GU
1
;
Jianfeng JI
;
Xiao ZHENG
Author Information
1. Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
- Publication Type:Review
- Keywords:
CXCL12;
CXCR4;
Metastasis;
Radiosensitivity;
Immune reaction
- From:
Chinese Journal of Radiological Medicine and Protection
2019;39(12):955-960
- CountryChina
- Language:Chinese
-
Abstract:
In addition to induce cell death in tumor cells, ionizing radiation (IR) regulates many biological behaviors of malignant tumors, such as intrinsic radiosensitivity, invasion and metastasis, angiogenesis, as well as immune response of tumor cells. The C-X-C motif chemokine ligand 12 (CXCL12) and its receptor CXCR4 are highly expressed in a variety of malignant tumors, and are involved in the process of remote metastasis, blood vessel formation, immune regulation, and therapeutic resistance of malignant tumors. Recent studies have found that the CXCL12/CXCR4 signal axis plays critical roles in the IR-regulated biological behavior of malignant tumors. This paper reviews the roles of CXCL12/CXCR4 signal axis in the biological behavior changes of irradiated malignant tumors.
