Advances in the role of HECT-type E3 ubiquitin ligases in tumors
10.3760/cma.j.issn.1673-4203.2020.02.014
- VernacularTitle: HECT型E3泛素连接酶在肿瘤中作用的研究现状和进展
- Author:
Zhimin LIU
1
;
Dousheng BAI
2
;
Chi ZHANG
2
;
Qian WANG
2
;
Rui PENG
2
Author Information
1. Dalian Medical University, Dalian 116044, China
2. Department of Hepatobiliary Surgery, Northern Jiangsu People′s Hospital; Institute of General Surgery; Clinical Medical College of Yangzhou University, Yangzhou 225001, China
- Publication Type:Review
- Keywords:
Ubiquitin-protein ligases;
Neoplasms;
Therapeutic uses;
HECT-type E3 ubiquitin ligases
- From:
International Journal of Surgery
2020;47(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of tumors is a complex process with multiple factors and multiple steps. Ubiquitination refers to a multi-step cascade of protein modification processes including ubiquitin, ubiquitin-activating enzyme, ubiquitin-binding enzyme, ubiquitin ligase and proteasome, which is important for maintaining eukaryotic homeostasis. mechanism. The E3 ubiquitin ligases family is an important component of the ubiquitin-proteasome system. This family includes many proteins that catalyze the ubiquitination of various protein substrates and promote their degradation by the proteasome system. Up to date, E3 ubiquitin ligases has played an important role in a variety of tumor cell biology processes, including cell proliferation, apoptosis and cycle regulation. HECT-type E3 ubiquitin ligases, one of the earliest studies of E3 ubiquitin ligases, is involved in the ubiquitination of transcriptional regulation of protein translation. This article reviews the recent research progress of HECT-type E3 ubiquitin ligases and its role in tumors.
