Relationship between apolipoprotein E gene polymorphism and cerebral infraction in Chinese type 2 diabetes mellitus patients
10.3760/cma.j.issn.1009-9158.2020.02.011
- VernacularTitle: 载脂蛋白E基因多态性与2型糖尿病患者发生脑梗死的相关性研究
- Author:
Xueying YU
1
;
Na WANG
2
;
Jiang LI
1
;
Liang MA
1
;
Yongtong CAO
1
Author Information
1. Laboratory Medicine, China-Japan Friendship Hospital, Beijing100029, China
2. Department of Transfusion Medicine, China-Japan Friendship Hospital, Beijing 100029, China
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Diabetic angiopathies;
Brain infarction;
Apolipoprotein E4;
Polymorphism, genetic
- From:
Chinese Journal of Laboratory Medicine
2020;43(2):160-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between apolipoprotein E (APOE) gene polymorphism and cerebral infraction (CI) in Chinese type 2 diabetes mellitus (T2DM) patients.
Methods:This study included 245 samples of T2DM patients without cerebral infraction (CON group) (Male/Female, 128/117) and 270 samples of T2DM patients with cerebral infraction (CI group)(Male/Female, 145/125) from the department of endocrinology and neurology utilizing real-time fluorescence quantitative PCR technique. The t test and χ2 test were used to compare the differences between the two groups.
Results:Patients with a history of hypertension in the CI group (84.12%) were significantly higher than those in the CON group (70.42%) (χ2=15.91, P<0.05).The systolic blood pressure (142.78±20.52)mmHg of the CI group was significantly higher than that of the CON group (133.89±18.58)mmHg (t=-5.16, P<0.05).Compared with CON group, the frequency of genotypes of ε2/ε3 and ε3/ε4 in CI group was significantly higher, while the frequency of ε3/ε3 genotype was significantly lower (χ2=11.48, P<0.05); the allele frequency of APOE ε4 was higher while ε3 was lower in CI group than that in CON group (χ2=7.00, P<0.05). Logistic regression analysis showed that hypertension history (OR=1.95, P<0.05), high systolic blood pressure (OR=1.02, P<0.05), APOE genotypes of ε2/ε3 (OR=2.08, P<0.05) and ε3/ε4 (OR=1.85, P<0.05) were independent risk factors for cerebral infarction in T2DM patients.
Conclusion:The polymorphism of APOE gene may be related to cerebral infraction in Chinese T2DM patients.
