Survival analysis and quality of life of pediatric low grade glioma treated by postoperative radiotherapy
10.3760/cma.j.issn.1004-4221.2020.02.003
- VernacularTitle: 儿童低级别胶质瘤术后放疗生存状态及生活质量分析
- Author:
Pengfei XING
1
;
Hangzhou WANG
2
;
Min CHEN
2
;
Ye TIAN
1
Author Information
1. Department of Radiation Oncology, Second Affiliated Hospital of Soochow University/Institute of Radiation Oncology of, Soochow University. Suzhou Key Laboratory for Radiation Oncology Suzhou 215004, China
2. Department of Neurosurgery, Children′s Hospital of Soochow University, Suzhou 215003, China
- Publication Type:Journal Article
- Keywords:
Pediatric low grade glioma/radiotherapy;
Survival;
Quality of life
- From:
Chinese Journal of Radiation Oncology
2020;29(2):93-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of children with low grade glioma (LGG) and evaluate their survival status and quality of life in LGG pediatric patients after postoperative radiotherapy.
Methods:Clinical data of 27 LGG children aged≤14 years admitted to Department of Radiation Oncology of our hospital from January 2011 to December 2017 were retrospectively analyzed. The 5-year overall survival (OS) and progression-free survival (PFS) were estimated with the Kaplan-Meier method.The quality of life was evaluated by body mass index (BMI), WeeFIM and enrollment situation.
Results:The 5-year OS and PFS of 27 pediatric patients were 92% and 87%. BMI was measured in 25 children who were still alive and the results showed that 1 child was slightly emaciated, 3 were overweight and 21 were normal. The total score of WeeFIM was> 108 in 21 cases and< 90 in 4 cases. In terms of social role-playing assessment, 5 cases delayed enrollment for≥ 2 years, 2 cases had good adaptation except the difficulties due to lameness, 7 of them had poor study performance, but had no communication barrier.
Conclusions:Children with LGG can obtain relatively excellent OS and PFS after postoperative radiotherapy. Part of the children with long-term survival may experience a declined quality of life, which is mainly manifested with a decline in motor and cognitive functions.
