Application and research progress of optogenetic technology in retinal diseases
10.3760/cma.j.issn.2095-0160.2020.02.012
- VernacularTitle: 光遗传技术在视网膜相关疾病的应用及研究进展
- Author:
Xiao LIN
1
;
Mingliang ZHANG
;
Xiaomin ZHANG
Author Information
1. Tianjin Key Laboratory of Retinal Functions and Diseases, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China
- Publication Type:Review
- Keywords:
Optogenetics;
Opsins;
Retinal diseases
- From:
Chinese Journal of Experimental Ophthalmology
2020;38(2):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Optogenetics is a technique combining optics and the power of light with genetics; it uses light-mediated protein-protein interactions to control the open/closed state of channels or the activation/inactivation states of signaling components within live cells.Recently developed optogenetic tools offer exciting opportunities by enabling signaling regulation with superior temporal and spatial resolution.The eye is a light-bioelectric conversion system.Compared with diseases of other organs, there are great advantages to apply optogenetics to the treatment of ophthalmic conditions, as new optical genetic tools are rapidly emerging.This article will focus on the main methods of optogenetic control of cells and the current status and outlook of its application in retinal diseases.
