Research progress in imaging characteristics of precancerous nodules in hepatocellular carcinoma cells
10.3760/cma.j.issn.1007-3418.2020.01.004
- VernacularTitle: 肝细胞癌癌前结节影像学特征的研究进展
- Author:
Fen GAO
1
;
Ping CAI
1
;
Chen LIU
1
;
Feng XIA
1
;
Jian WANG
1
Author Information
1. Department of Radiology, the First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038, China
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Diagnosis, imaging;
Precancerous lesions;
High-grade dysplastic nodule;
Contrast media
- From:
Chinese Journal of Hepatology
2020;28(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocarcinogenesis is a multi-step process in which detection of precancerous lesions and advanced hepatocellular carcinoma in its progressive stage is crucially important for predicting tumor behavior, estimating the extent of lesions, implementing the optimal treatment strategy, and improving the survival of patients. The rapid development and wide application of liver imaging technology, especially the application of hepatocyte-specific gadoxetate disodium MRI contrast agent (Gd-EOB-DTPA MRI), not only provide information on vascular changes of liver nodules and hepatocyte function, but also has become a precise diagnostic method for differentiating cirrhotic regenerative nodule (RN), low-grade dysplastic nodule (LGDN), high-grade dysplastic nodule (HGDN), early hepatocellular carcinoma and HCC. Hence, the risk for malignant progression is stratified. This review summarizes the value of Gd-EOB-DTPA MRI for early HCC diagnosis and analyzes the key concepts in the multi-step process of HCC development as well as the imaging manifestations of precancerous lesions that may eventually be transformed into typical HCC.
