Exposure to famine in fetus and infant period and risk for hypertension in adulthood
10.3760/cma.j.issn.0254-6450.2020.01.014
- VernacularTitle: 生命早期饥荒暴露与成年期高血压患病风险的关联分析
- Author:
Yueyue YOU
1
;
Yan SONG
2
;
Mohan WANG
2
;
Lili ZHANG
2
;
Wei BAI
2
;
Weiying YU
2
;
Yaqin YU
2
;
Changgui KOU
2
Author Information
1. Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China; Health Education Division, Center for Chronic Disease Control, Nanshan District, Shenzhen 518000, China
2. Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China
- Publication Type:Journal Article
- Keywords:
Fetal exposure;
Famine;
Hypertension;
Malnutrition
- From:
Chinese Journal of Epidemiology
2020;41(1):74-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between exposure to famine in fetus and infant period and the risks for hypertension in adulthood.
Methods:A total of 5 960 participants born between 1956 and 1965 were included in the study and were divided into unexposed group (1963-1965), fetal exposed group (1959-1961), early- childhood exposed group (1956-1958) and transitional group (1962). Logistic regression model was used to explore the association between famine exposure in early life and the risk for hypertension in adulthood.
Results:Both the fetal exposure and the early-childhood exposure were the risk factors for hypertension in adulthood (OR=1.249, 95%CI: 1.049-1.486 and OR=1.360, 95%CI: 1.102-1.679). Meanwhile, in rural area, compared with unexposed group, the fetal exposure (OR=1.401, 95%CI: 1.091-1.798) and the early-childhood exposure (OR=1.460, 95%CI: 1.145-1.862) were also associated with a greater risk of hypertension in adulthood. In addition, fetal exposure and early-childhood exposure to famine in women were associated with 36.0% and 31.9% increased risks for hypertension (95%CI: 7.8%-71.7% and 95%CI: 4.8%-66.0%) according to the stratified analysis.
Conclusion:Fetal exposure to famine might increase the risk for hypertension in adulthood.
