Application Status and Research Progress of External Traditional Chinese Medicine Ointment for Rheumatism Treatment
10.13422/j.cnki.syfjx.20181808
- VernacularTitle: 用于风湿病治疗的中药外用膏剂的应用现状及研究进展
- Author:
Jian FAN
1
;
Ying SHEN
1
;
Juan-ping ZHAO
1
;
Xue-qing SUN
1
;
Feng GUAN
1
;
Feng-juan HAN
1
;
Yan-hong WANG
1
Author Information
1. Heilongjiang University of Chinese Medicine, Harbin 150040, China
- Publication Type:Research Article
- Keywords:
external traditional Chinese medicine ointment;
rheumatism;
application status;
pharmacodynamics;
forming process;
transdermal behavior;
safety
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(2):206-213
- CountryChina
- Language:Chinese
-
Abstract:
Due to the definite curative effect,stable drug properties and low incidence of adverse reactions,the external traditional Chinese medicine(TCM) ointment for rheumatism treatment has attracted more and more attention from scholars at home and abroad.Based on the external TCM ointment for the treatment of rheumatism approved by China Food and Drug Administration(CFDA),this paper would comb and analyze their dosage forms,varieties,specifications,etc.On the other hand,this article summarizes the application of the new formulation technology,prescription research,study on the forming process,pharmacodynamics and safety research,etc.The problems existing in this area were pointed out,such as lack of new preparations;less research on the penetration material basis,the penetration enhancing mechanism,and the penetration enhancing law;the selection of detection indicators of quality control standards is not comprehensive enough;qualitative and quantitative studies of pharmacokinetics are relatively scarce and so on.Meanwhile,proper measures and suggestions are put forward.Not only the formulation classification and specification description of external TCM ointment should be standardized,but also new dosage forms such as intelligentized,controlled release and targeted preparations of Chinese medicine should be actively introduced;the study of transdermal activity of transdermal enhancer itself should be strengthened,and investigating the correlation between the transdermal absorption of the agent itself and promoting transdermal absorption;the biological effect index or indicators that combine chemical and biological effects should be used,and learning from the latest research achievements of multidimensional spectroscopy of Chinese herbal medicine,thereby establishing scientific detection indicators and quality control methods that conform to modern transdermal concept.
