Clinical Effect of Jiawei Xijiao Dihuang Tang on Henoch-Schonlein Purpura Nephritis of Children with Blood Heat and Stasis Syndrome
10.13422/j.cnki.syfjx.20190231
- VernacularTitle: 加味犀角地黄汤辨治儿童紫癜性肾炎血热夹瘀证的临床观察
- Author:
Yu-fang QIN
1
;
Gui-ping LI
1
Author Information
1. Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University, Luzhou 646000, China
- Publication Type:Research Article
- Keywords:
henoch-schonlein purpura nephritis;
blood heat and stasis syndrome;
Xijiao Dihuang Tang;
anti-inflammation;
coagulation function;
renal function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(2):144-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effect of Jiawei Xijiao Dihuang Tang on Henoch-schonlein purpura nephritis of children with blood heat and stasis syndrome and the inflammatory factors and coagulation function. Method:One hundred and twenty-two patients were divided into control group (60 cases) and observation group (62 cases) by random number table. Patients in control group got prednisolone acetate tablets every day, 1.5-2 mg·kg-1·d-1, after 4 weeks, of the treatment, and the 4 weeks dosage decreased progressively. Patients in control group also got dipyridamole tablets, 3-5 mg·kg-1·d-1, and compound rutin tablets, 1 tablet/day, 3 times/days. In addition to the therapy of control group, patients in observation group were also given Jiawei Xijiao Dihuang Tang, 1 dose/day. And one course of treatment was 12 weeks. Before and after treatment, blood heat and stasis syndrome were graded. And levels of urinary β2 microglobulin (β2-MG), 24-hour urine protein quantitative (24 h UmAlb), microalbuminuria (mAlb), cystatin C (CysC), platelet count (PLT), plasma prothrombin time (PLT), plasma prothrombin time (PT), activated partial thromboplastin time (APTT), interleukins-2 (IL-2), IL-4, IL-10, tumor necrosis factor-α (TNF-α), von willebrand factor (vWF), platelet activating factor (PAF), thrombomodulin (TM), plasma fibrinogen (FIB), urine RBC and urine protein (PRO) were detected. Result:The total clinical effect in observation group was 95.16%, which was higher than 81.54% in control group (χ2=5.466, P<0.05). And the total symptoms of traditional Chinese medicine(TCM)was 96.77%, which was higher than 75% in control groups (χ2=12.052, P<0.01). After treatment, levels of β2-MG, 24 h UmAlb, mAlb and CysC were higher than those in control groups (P<0.01). And PT in both groups prolonged, particularly in observation group (P<0.05). Level of FIB in observation group was lower than that in control groups (P<0.05). And levels of IL-4, IL-10, TNF-α and vWF, PAF and TM were lower than those in control groups, but level of IL-2 was higher than that in control groups (P<0.01). Conclusion:In addition to the hormone therapy, Jiawei Xijiao Dihuang Tang can protect renal function, relieve symptoms of proteinuria and hematuria, with the effects of resisting inflammation and alleviating coagulation function.
